The renin-angiotensin system and its blockers
Research on the renin-angiotensin system (RAS) has contributed significantly to advances in understanding cardiovascular and renal homeostasis and to the treatment of cardiovascular diseases. This review offers a brief history of the RAS with an overview of its major components and their fu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society
2014-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791412756I.pdf |
| _version_ | 1818452267191238656 |
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| author | Igić Rajko Škrbić Ranko |
| author_facet | Igić Rajko Škrbić Ranko |
| author_sort | Igić Rajko |
| collection | DOAJ |
| description | Research on the renin-angiotensin system (RAS) has contributed significantly
to advances in understanding cardiovascular and renal homeostasis and to the
treatment of cardiovascular diseases. This review offers a brief history of
the RAS with an overview of its major components and their functions, as well
as blockers of the RAS, their clinical usage and current research that
targets various components of the RAS. Because angiotensin-converting enzyme
(ACE) metabolizes two biologically active peptides, one in the
kallikrein-kinin system (KKS) and one in the RAS, it is the essential
connection between the two systems. ACE releases very powerful hypertensive
agent, angiotensin II and also inactivates strong hypotensive peptide,
bradykinin. Inhibition of ACE thus has a dual effect, resulting in decreased
angiotensin II and increased bradykinin. We described the KKS as well. |
| first_indexed | 2024-12-14T21:20:22Z |
| format | Article |
| id | doaj.art-0eea8ff5428547f684c1513218209dca |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-14T21:20:22Z |
| publishDate | 2014-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-0eea8ff5428547f684c1513218209dca2022-12-21T22:46:57ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792014-01-0114211-1275676310.2298/SARH1412756I0370-81791412756IThe renin-angiotensin system and its blockersIgić Rajko0Škrbić Ranko1John Stroger Hospital of Cook County, Department of Anesthesiology and Pain Management, Chicago, USA + University of Banja Luka, Medical Faculty, Department of Clinical Pharmacology, Banja Luka, Republic of Srpska, Bosnia and HerzegovinaUniversity of Banja Luka, Medical Faculty, Department of Clinical Pharmacology, Banja Luka, Republic of Srpska, Bosnia and HerzegovinaResearch on the renin-angiotensin system (RAS) has contributed significantly to advances in understanding cardiovascular and renal homeostasis and to the treatment of cardiovascular diseases. This review offers a brief history of the RAS with an overview of its major components and their functions, as well as blockers of the RAS, their clinical usage and current research that targets various components of the RAS. Because angiotensin-converting enzyme (ACE) metabolizes two biologically active peptides, one in the kallikrein-kinin system (KKS) and one in the RAS, it is the essential connection between the two systems. ACE releases very powerful hypertensive agent, angiotensin II and also inactivates strong hypotensive peptide, bradykinin. Inhibition of ACE thus has a dual effect, resulting in decreased angiotensin II and increased bradykinin. We described the KKS as well.http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791412756I.pdfrenin-angiotensin systemangiotensin IIbradykininACE inhibitorsangiotensin receptorblockersaliskiren |
| spellingShingle | Igić Rajko Škrbić Ranko The renin-angiotensin system and its blockers Srpski Arhiv za Celokupno Lekarstvo renin-angiotensin system angiotensin II bradykinin ACE inhibitors angiotensin receptorblockers aliskiren |
| title | The renin-angiotensin system and its blockers |
| title_full | The renin-angiotensin system and its blockers |
| title_fullStr | The renin-angiotensin system and its blockers |
| title_full_unstemmed | The renin-angiotensin system and its blockers |
| title_short | The renin-angiotensin system and its blockers |
| title_sort | renin angiotensin system and its blockers |
| topic | renin-angiotensin system angiotensin II bradykinin ACE inhibitors angiotensin receptorblockers aliskiren |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791412756I.pdf |
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