Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition
Quantitative susceptibility mapping (QSM) has been successfully applied to study changes in deep grey matter nuclei as well as in lesional tissue, but its application to white matter has been complicated by the observed orientation dependence of gradient echo signal. The anisotropic susceptibility t...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | NeuroImage: Clinical |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158222001243 |
| _version_ | 1817977286435012608 |
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| author | Renat Sibgatulin Daniel Güllmar Andreas Deistung Christian Enzinger Stefan Ropele Jürgen R. Reichenbach |
| author_facet | Renat Sibgatulin Daniel Güllmar Andreas Deistung Christian Enzinger Stefan Ropele Jürgen R. Reichenbach |
| author_sort | Renat Sibgatulin |
| collection | DOAJ |
| description | Quantitative susceptibility mapping (QSM) has been successfully applied to study changes in deep grey matter nuclei as well as in lesional tissue, but its application to white matter has been complicated by the observed orientation dependence of gradient echo signal. The anisotropic susceptibility tensor is thought to be at the origin of this orientation dependence, and magnetic susceptibility anisotropy (MSA) derived from this tensor has been proposed as a marker of the state and integrity of the myelin sheath and may therefore be of particular interest for the study of demyelinating pathologies such as multiple sclerosis (MS). Reconstruction of the susceptibility tensor, however, requires repeated measurements with multiple head orientations, rendering the approach impractical for clinical applications.In this study, we combined single-orientation QSM with fibre orientation information to assess apparent MSA in three white matter tracts, i.e., optic radiation (OR), splenium of the corpus callosum (SCC), and superior longitudinal fascicle (SLF), in two cohorts of 64 healthy controls and 89 MS patients. The apparent MSA showed a significant decrease in optic radiation in the MS cohort compared with healthy controls. It decreased in the MS cohort with increasing lesion load in OR and with disease duration in the splenium. All of this suggests demyelination in normal appearing white matter. However, the apparent MSA observed in the SLF pointed to potential systematic issues that require further exploration to realize the full potential of the presented approach. Despite the limitations of such single-orientation ROI-specific estimation, we believe that our clinically feasible approach to study degenerative changes in WM is worthy of further investigation. |
| first_indexed | 2024-04-13T22:14:17Z |
| format | Article |
| id | doaj.art-0eead0c6d7cf4421869db1a5ee28c727 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-04-13T22:14:17Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-0eead0c6d7cf4421869db1a5ee28c7272022-12-22T02:27:35ZengElsevierNeuroImage: Clinical2213-15822022-01-0135103059Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisitionRenat Sibgatulin0Daniel Güllmar1Andreas Deistung2Christian Enzinger3Stefan Ropele4Jürgen R. Reichenbach5Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital — Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany; Corresponding author.Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital — Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, GermanyUniversity Clinic and Outpatient Clinic for Radiology, Department for Radiation Medicine, University Hospital Halle (Saale), Ernst-Grube-Str. 40, 06120 Halle (Saale), GermanyDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, AustriaDepartment of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, AustriaMedical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital — Friedrich Schiller University Jena, Philosophenweg 3, 07743 Jena, Germany; Michael Stifel Center Jena for Data-Driven and Simulation Science, Friedrich-Schiller-University Jena, Jena, GermanyQuantitative susceptibility mapping (QSM) has been successfully applied to study changes in deep grey matter nuclei as well as in lesional tissue, but its application to white matter has been complicated by the observed orientation dependence of gradient echo signal. The anisotropic susceptibility tensor is thought to be at the origin of this orientation dependence, and magnetic susceptibility anisotropy (MSA) derived from this tensor has been proposed as a marker of the state and integrity of the myelin sheath and may therefore be of particular interest for the study of demyelinating pathologies such as multiple sclerosis (MS). Reconstruction of the susceptibility tensor, however, requires repeated measurements with multiple head orientations, rendering the approach impractical for clinical applications.In this study, we combined single-orientation QSM with fibre orientation information to assess apparent MSA in three white matter tracts, i.e., optic radiation (OR), splenium of the corpus callosum (SCC), and superior longitudinal fascicle (SLF), in two cohorts of 64 healthy controls and 89 MS patients. The apparent MSA showed a significant decrease in optic radiation in the MS cohort compared with healthy controls. It decreased in the MS cohort with increasing lesion load in OR and with disease duration in the splenium. All of this suggests demyelination in normal appearing white matter. However, the apparent MSA observed in the SLF pointed to potential systematic issues that require further exploration to realize the full potential of the presented approach. Despite the limitations of such single-orientation ROI-specific estimation, we believe that our clinically feasible approach to study degenerative changes in WM is worthy of further investigation.http://www.sciencedirect.com/science/article/pii/S2213158222001243Multiple sclerosisQuantitative susceptibility mappingOrientation dependenceWhite matterMagnetic susceptibility anisotropyTissue microstructure |
| spellingShingle | Renat Sibgatulin Daniel Güllmar Andreas Deistung Christian Enzinger Stefan Ropele Jürgen R. Reichenbach Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition NeuroImage: Clinical Multiple sclerosis Quantitative susceptibility mapping Orientation dependence White matter Magnetic susceptibility anisotropy Tissue microstructure |
| title | Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition |
| title_full | Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition |
| title_fullStr | Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition |
| title_full_unstemmed | Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition |
| title_short | Magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single-orientation acquisition |
| title_sort | magnetic susceptibility anisotropy in normal appearing white matter in multiple sclerosis from single orientation acquisition |
| topic | Multiple sclerosis Quantitative susceptibility mapping Orientation dependence White matter Magnetic susceptibility anisotropy Tissue microstructure |
| url | http://www.sciencedirect.com/science/article/pii/S2213158222001243 |
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