<i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes
Oomycetes are pathogens of plants and animals, which cause billions of dollars of global losses to the agriculture, aquaculture and forestry sectors each year. These organisms superficially resemble fungi, with an archetype being <i>Phytophthora infestans</i>, the cause of late blight of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/10/11/2157 |
| _version_ | 1827645974053388288 |
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| author | Indu Muraleedharan Nair Emma Condon Barbara Doyle Prestwich John James Mackrill |
| author_facet | Indu Muraleedharan Nair Emma Condon Barbara Doyle Prestwich John James Mackrill |
| author_sort | Indu Muraleedharan Nair |
| collection | DOAJ |
| description | Oomycetes are pathogens of plants and animals, which cause billions of dollars of global losses to the agriculture, aquaculture and forestry sectors each year. These organisms superficially resemble fungi, with an archetype being <i>Phytophthora infestans</i>, the cause of late blight of tomatoes and potatoes. Comparison of the physiology of oomycetes with that of other organisms, such as plants and animals, may provide new routes to selectively combat these pathogens. In most eukaryotes, <i>myo</i>-inositol 1,4,5 trisphosphate is a key second messenger that links extracellular stimuli to increases in cytoplasmic Ca<sup>2+</sup>, to regulate cellular activities. In the work presented in this study, investigation of the molecular components of <i>myo</i>-inositol 1,4,5 trisphosphate signaling in oomycetes has unveiled similarities and differences with that in other eukaryotes. Most striking is that several oomycete species lack detectable phosphoinositide-selective phospholipase C homologues, the enzyme family that generates this second messenger, but still possess relatives of <i>myo</i>-inositol 1,4,5 trisphosphate-gated Ca<sup>2+</sup>-channels. |
| first_indexed | 2024-03-09T18:49:35Z |
| format | Article |
| id | doaj.art-0eed33f364a44fd5ad4085dc189f91d9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-09T18:49:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-0eed33f364a44fd5ad4085dc189f91d92023-11-24T05:56:40ZengMDPI AGMicroorganisms2076-26072022-10-011011215710.3390/microorganisms10112157<i>Myo</i>-D-inositol Trisphosphate Signalling in OomycetesIndu Muraleedharan Nair0Emma Condon1Barbara Doyle Prestwich2John James Mackrill3Department of Physiology, School of Medicine, University College Cork (UCC), T12 YT20 Cork, IrelandDepartment of Physiology, School of Medicine, University College Cork (UCC), T12 YT20 Cork, IrelandDepartment of Plant Science, School of Biological, Earth and Environmental Sciences, University College Cork (UCC), T23 TK30 Cork, IrelandDepartment of Physiology, School of Medicine, University College Cork (UCC), T12 YT20 Cork, IrelandOomycetes are pathogens of plants and animals, which cause billions of dollars of global losses to the agriculture, aquaculture and forestry sectors each year. These organisms superficially resemble fungi, with an archetype being <i>Phytophthora infestans</i>, the cause of late blight of tomatoes and potatoes. Comparison of the physiology of oomycetes with that of other organisms, such as plants and animals, may provide new routes to selectively combat these pathogens. In most eukaryotes, <i>myo</i>-inositol 1,4,5 trisphosphate is a key second messenger that links extracellular stimuli to increases in cytoplasmic Ca<sup>2+</sup>, to regulate cellular activities. In the work presented in this study, investigation of the molecular components of <i>myo</i>-inositol 1,4,5 trisphosphate signaling in oomycetes has unveiled similarities and differences with that in other eukaryotes. Most striking is that several oomycete species lack detectable phosphoinositide-selective phospholipase C homologues, the enzyme family that generates this second messenger, but still possess relatives of <i>myo</i>-inositol 1,4,5 trisphosphate-gated Ca<sup>2+</sup>-channels.https://www.mdpi.com/2076-2607/10/11/2157oomycetecalcium<i>myo</i>-inositol 1,4,5 trisphosphate |
| spellingShingle | Indu Muraleedharan Nair Emma Condon Barbara Doyle Prestwich John James Mackrill <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes Microorganisms oomycete calcium <i>myo</i>-inositol 1,4,5 trisphosphate |
| title | <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes |
| title_full | <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes |
| title_fullStr | <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes |
| title_full_unstemmed | <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes |
| title_short | <i>Myo</i>-D-inositol Trisphosphate Signalling in Oomycetes |
| title_sort | i myo i d inositol trisphosphate signalling in oomycetes |
| topic | oomycete calcium <i>myo</i>-inositol 1,4,5 trisphosphate |
| url | https://www.mdpi.com/2076-2607/10/11/2157 |
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