Diversity Models and Applications of 3D Breast Tumor-on-a-Chip
Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years. Novel diagnostic and therapeutic approaches are needed to break the stalemate. An organ-on-chip approach is co...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/12/7/814 |
| _version_ | 1797526566232653824 |
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| author | Kena Song Xiangyang Zu Zhe Du Zhigang Hu Jingjing Wang Jinghua Li |
| author_facet | Kena Song Xiangyang Zu Zhe Du Zhigang Hu Jingjing Wang Jinghua Li |
| author_sort | Kena Song |
| collection | DOAJ |
| description | Breast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years. Novel diagnostic and therapeutic approaches are needed to break the stalemate. An organ-on-chip approach is considered due to its ability to repeat the real conditions found in the body on microfluidic chips, offsetting the shortcomings of traditional 2D culture and animal tests. In recent years, the organ-on-chip approach has shown diversity, recreating the structure and functional units of the real organs/tissues. The applications were also developed rapidly from the laboratory to the industrialized market. This review focuses on breast tumor-on-a-chip approaches concerning the diversity models and applications. The models are summarized and categorized by typical biological reconstitution, considering the design and fabrication of the various breast models. The breast tumor-on-a-chip approach is a typical representative of organ chips, which are one of the precedents in the market. The applications are roughly divided into two categories: fundamental mechanism research and biological medicine. Finally, we discuss the prospect and deficiencies of the emerging technology. It has excellent prospects in all of the application fields, however there exist some deficiencies for promotion, such as the stability of the structure and function, and uniformity for quantity production. |
| first_indexed | 2024-03-10T09:31:08Z |
| format | Article |
| id | doaj.art-0eeed81c44ee46088b01969795d9355b |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-10T09:31:08Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-0eeed81c44ee46088b01969795d9355b2023-11-22T04:24:57ZengMDPI AGMicromachines2072-666X2021-07-0112781410.3390/mi12070814Diversity Models and Applications of 3D Breast Tumor-on-a-ChipKena Song0Xiangyang Zu1Zhe Du2Zhigang Hu3Jingjing Wang4Jinghua Li5College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, ChinaBreast disease is one of the critical diseases that plague females, as is known, breast cancer has high mortality, despite significant pathophysiological progress during the past few years. Novel diagnostic and therapeutic approaches are needed to break the stalemate. An organ-on-chip approach is considered due to its ability to repeat the real conditions found in the body on microfluidic chips, offsetting the shortcomings of traditional 2D culture and animal tests. In recent years, the organ-on-chip approach has shown diversity, recreating the structure and functional units of the real organs/tissues. The applications were also developed rapidly from the laboratory to the industrialized market. This review focuses on breast tumor-on-a-chip approaches concerning the diversity models and applications. The models are summarized and categorized by typical biological reconstitution, considering the design and fabrication of the various breast models. The breast tumor-on-a-chip approach is a typical representative of organ chips, which are one of the precedents in the market. The applications are roughly divided into two categories: fundamental mechanism research and biological medicine. Finally, we discuss the prospect and deficiencies of the emerging technology. It has excellent prospects in all of the application fields, however there exist some deficiencies for promotion, such as the stability of the structure and function, and uniformity for quantity production.https://www.mdpi.com/2072-666X/12/7/814breast tumor-on-a-chipbreast modelsapplications |
| spellingShingle | Kena Song Xiangyang Zu Zhe Du Zhigang Hu Jingjing Wang Jinghua Li Diversity Models and Applications of 3D Breast Tumor-on-a-Chip Micromachines breast tumor-on-a-chip breast models applications |
| title | Diversity Models and Applications of 3D Breast Tumor-on-a-Chip |
| title_full | Diversity Models and Applications of 3D Breast Tumor-on-a-Chip |
| title_fullStr | Diversity Models and Applications of 3D Breast Tumor-on-a-Chip |
| title_full_unstemmed | Diversity Models and Applications of 3D Breast Tumor-on-a-Chip |
| title_short | Diversity Models and Applications of 3D Breast Tumor-on-a-Chip |
| title_sort | diversity models and applications of 3d breast tumor on a chip |
| topic | breast tumor-on-a-chip breast models applications |
| url | https://www.mdpi.com/2072-666X/12/7/814 |
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