Causal Association between Periodontal Diseases and Cardiovascular Diseases
Observational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR)...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/13/1/13 |
| _version_ | 1797493822755700736 |
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| author | Mengchen Zhou Jiangtao Dong Lingfeng Zha Yuhua Liao |
| author_facet | Mengchen Zhou Jiangtao Dong Lingfeng Zha Yuhua Liao |
| author_sort | Mengchen Zhou |
| collection | DOAJ |
| description | Observational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR) studies were carried out to assess the association between genetic liability for periodontal diseases (dental caries and periodontitis) and major CVDs, including coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke—including ischemic stroke as well as its three main subtypes—based on large-scale genome-wide association studies (GWASs). Our two-sample MR analyses did not provide evidence for dental caries and periodontitis as the causes of cardiovascular diseases; sensitivity analyses, including MR–Egger analysis and weighted median analysis, also supported this result. Gene functional annotation and pathway enrichment analyses indicated the common pathophysiology between cardiovascular diseases and periodontal diseases. The associations from observational studies may be explained by shared risk factors and comorbidities instead of direct consequences. This also suggests that addressing the common risk factors—such as reducing obesity and improving glucose tolerance—could benefit both conditions. |
| first_indexed | 2024-03-10T01:25:29Z |
| format | Article |
| id | doaj.art-0ef0aa61bec145c2a0afbd081aca0041 |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T01:25:29Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-0ef0aa61bec145c2a0afbd081aca00412023-11-23T13:50:54ZengMDPI AGGenes2073-44252021-12-011311310.3390/genes13010013Causal Association between Periodontal Diseases and Cardiovascular DiseasesMengchen Zhou0Jiangtao Dong1Lingfeng Zha2Yuhua Liao3Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaDepartment of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, ChinaObservational studies have revealed that dental diseases such as periodontitis and dental caries increase the risk of cardiovascular diseases (CVDs). However, the causality between periodontal disease (PD) and CVDs is still not clarified. In the present study, two-sample Mendelian randomization (MR) studies were carried out to assess the association between genetic liability for periodontal diseases (dental caries and periodontitis) and major CVDs, including coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), and stroke—including ischemic stroke as well as its three main subtypes—based on large-scale genome-wide association studies (GWASs). Our two-sample MR analyses did not provide evidence for dental caries and periodontitis as the causes of cardiovascular diseases; sensitivity analyses, including MR–Egger analysis and weighted median analysis, also supported this result. Gene functional annotation and pathway enrichment analyses indicated the common pathophysiology between cardiovascular diseases and periodontal diseases. The associations from observational studies may be explained by shared risk factors and comorbidities instead of direct consequences. This also suggests that addressing the common risk factors—such as reducing obesity and improving glucose tolerance—could benefit both conditions.https://www.mdpi.com/2073-4425/13/1/13periodontal diseasescardiovascular diseasescausal associationMendelian randomization |
| spellingShingle | Mengchen Zhou Jiangtao Dong Lingfeng Zha Yuhua Liao Causal Association between Periodontal Diseases and Cardiovascular Diseases Genes periodontal diseases cardiovascular diseases causal association Mendelian randomization |
| title | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
| title_full | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
| title_fullStr | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
| title_full_unstemmed | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
| title_short | Causal Association between Periodontal Diseases and Cardiovascular Diseases |
| title_sort | causal association between periodontal diseases and cardiovascular diseases |
| topic | periodontal diseases cardiovascular diseases causal association Mendelian randomization |
| url | https://www.mdpi.com/2073-4425/13/1/13 |
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