Tau Pathology in Parkinson's Disease
Tau protein—a member of the microtubule-associated protein family—is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feat...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fneur.2018.00809/full |
| _version_ | 1828433077732376576 |
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| author | Xue Zhang Fei Gao Dongdong Wang Chao Li Yi Fu Wei He Jianmin Zhang |
| author_facet | Xue Zhang Fei Gao Dongdong Wang Chao Li Yi Fu Wei He Jianmin Zhang |
| author_sort | Xue Zhang |
| collection | DOAJ |
| description | Tau protein—a member of the microtubule-associated protein family—is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feature are called tauopathies. Parkinson's disease (PD) was not initially considered to be a typical tauopathy. However, recent studies have demonstrated increasing evidence of tau pathology in PD. A genome-wide association (GWA) study indicated a potential association between tauopathy and sporadic PD. The aggregation and deposition of tau were also observed in ~50% of PD brains, and it seems to be transported from neuron to neuron. The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism. |
| first_indexed | 2024-12-10T18:30:07Z |
| format | Article |
| id | doaj.art-0ef17921932043e98cf07ecd0fe37a4b |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-10T18:30:07Z |
| publishDate | 2018-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-0ef17921932043e98cf07ecd0fe37a4b2022-12-22T01:37:58ZengFrontiers Media S.A.Frontiers in Neurology1664-22952018-10-01910.3389/fneur.2018.00809287858Tau Pathology in Parkinson's DiseaseXue ZhangFei GaoDongdong WangChao LiYi FuWei HeJianmin ZhangTau protein—a member of the microtubule-associated protein family—is a key protein involved in many neurodegenerative diseases. Tau pathology in neurodegenerative diseases is characterized by pathological tau aggregation in neurofibrillary tangles (NFTs). Diseases with this typical pathological feature are called tauopathies. Parkinson's disease (PD) was not initially considered to be a typical tauopathy. However, recent studies have demonstrated increasing evidence of tau pathology in PD. A genome-wide association (GWA) study indicated a potential association between tauopathy and sporadic PD. The aggregation and deposition of tau were also observed in ~50% of PD brains, and it seems to be transported from neuron to neuron. The aggregation of NFTs, the abnormal hyperphosphorylation of tau protein, and the interaction between tau and alpha-synuclein may all contribute to the cell death and poor axonal transport observed in PD and Parkinsonism.https://www.frontiersin.org/article/10.3389/fneur.2018.00809/fulltauopathyParkinson's disease (PD)hyperphosphorylationalpha-synuclientau protein |
| spellingShingle | Xue Zhang Fei Gao Dongdong Wang Chao Li Yi Fu Wei He Jianmin Zhang Tau Pathology in Parkinson's Disease Frontiers in Neurology tauopathy Parkinson's disease (PD) hyperphosphorylation alpha-synuclien tau protein |
| title | Tau Pathology in Parkinson's Disease |
| title_full | Tau Pathology in Parkinson's Disease |
| title_fullStr | Tau Pathology in Parkinson's Disease |
| title_full_unstemmed | Tau Pathology in Parkinson's Disease |
| title_short | Tau Pathology in Parkinson's Disease |
| title_sort | tau pathology in parkinson s disease |
| topic | tauopathy Parkinson's disease (PD) hyperphosphorylation alpha-synuclien tau protein |
| url | https://www.frontiersin.org/article/10.3389/fneur.2018.00809/full |
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