Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications
Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-07-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2079-6382/7/3/55 |
| _version_ | 1818916663748198400 |
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| author | Mark A. Isaacs Brunella Barbero Lee J. Durndell Anthony C. Hilton Luca Olivi Christopher M. A. Parlett Karen Wilson Adam F. Lee |
| author_facet | Mark A. Isaacs Brunella Barbero Lee J. Durndell Anthony C. Hilton Luca Olivi Christopher M. A. Parlett Karen Wilson Adam F. Lee |
| author_sort | Mark A. Isaacs |
| collection | DOAJ |
| description | Healthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA). |
| first_indexed | 2024-12-20T00:21:45Z |
| format | Article |
| id | doaj.art-0ef3f0ef87fa4ee69e31e6b484918e57 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-12-20T00:21:45Z |
| publishDate | 2018-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-0ef3f0ef87fa4ee69e31e6b484918e572022-12-21T20:00:09ZengMDPI AGAntibiotics2079-63822018-07-01735510.3390/antibiotics7030055antibiotics7030055Tunable Silver-Functionalized Porous Frameworks for Antibacterial ApplicationsMark A. Isaacs0Brunella Barbero1Lee J. Durndell2Anthony C. Hilton3Luca Olivi4Christopher M. A. Parlett5Karen Wilson6Adam F. Lee7Department of Chemistry, University College London, London WC1H 0AJ, UKEuropean Bioenergy Research Institute, Aston University, Birmingham B4 7ET, UKInorganic Chemistry and Catalysis, Debye Institute for Nanomaterials Science, Utrect University, Universiteitsweg 99, 3584 CG Utrecht, The NetherlandsLife and Health Sciences, Aston University, Birmingham B4 7ET, UKSincrotrone Trieste, 34149 Basovizza, ItalyEuropean Bioenergy Research Institute, Aston University, Birmingham B4 7ET, UKSchool of Science, RMIT University, Melbourne, VIC 3001, AustraliaSchool of Science, RMIT University, Melbourne, VIC 3001, AustraliaHealthcare-associated infections and the rise of drug-resistant bacteria pose significant challenges to existing antibiotic therapies. Silver nanocomposites are a promising solution to the current crisis, however their therapeutic application requires improved understanding of underpinning structure-function relationships. A family of chemically and structurally modified mesoporous SBA-15 silicas were synthesized as porous host matrices to tune the physicochemical properties of silver nanoparticles. Physicochemical characterization by transmission electron microscopy (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectroscopy (XANES) and porosimetry demonstrate that functionalization by a titania monolayer and the incorporation of macroporosity both increase silver nanoparticle dispersion throughout the silica matrix, thereby promoting Ag2CO3 formation and the release of ionic silver in simulated tissue fluid. The Ag2CO3 concentration within functionalized porous architectures is a strong predictor for antibacterial efficacy against a broad spectrum of pathogens, including C. difficile and methicillin-resistant Staphylococcus aureus (MRSA).http://www.mdpi.com/2079-6382/7/3/55silverantibacterialtitaniamesoporousmacroporoussurface functionalization |
| spellingShingle | Mark A. Isaacs Brunella Barbero Lee J. Durndell Anthony C. Hilton Luca Olivi Christopher M. A. Parlett Karen Wilson Adam F. Lee Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications Antibiotics silver antibacterial titania mesoporous macroporous surface functionalization |
| title | Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications |
| title_full | Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications |
| title_fullStr | Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications |
| title_full_unstemmed | Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications |
| title_short | Tunable Silver-Functionalized Porous Frameworks for Antibacterial Applications |
| title_sort | tunable silver functionalized porous frameworks for antibacterial applications |
| topic | silver antibacterial titania mesoporous macroporous surface functionalization |
| url | http://www.mdpi.com/2079-6382/7/3/55 |
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