Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components
Cells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function. Oxidative...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2021.673002/full |
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| author | Susana G. Martins Susana G. Martins Rita Zilhão Rita Zilhão Sólveig Thorsteinsdóttir Sólveig Thorsteinsdóttir Ana Rita Carlos Ana Rita Carlos |
| author_facet | Susana G. Martins Susana G. Martins Rita Zilhão Rita Zilhão Sólveig Thorsteinsdóttir Sólveig Thorsteinsdóttir Ana Rita Carlos Ana Rita Carlos |
| author_sort | Susana G. Martins |
| collection | DOAJ |
| description | Cells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function. Oxidative stress, caused by excess ROS, and DNA damage, triggered in response to different sources, are countered and resolved by specific mechanisms, allowing the normal physiological equilibrium of cells and tissues to be restored. One process that is affected by oxidative stress and DNA damage is extracellular matrix (ECM) remodeling, which is a continuous and highly controlled mechanism that allows tissues to readjust in reaction to different challenges. The crosstalk between oxidative stress/DNA damage and ECM remodeling is not unidirectional. Quite on the contrary, mutations in ECM genes have a strong impact on tissue homeostasis and are characterized by increased oxidative stress and potentially also accumulation of DNA damage. In this review, we will discuss how oxidative stress and DNA damage affect the expression and deposition of ECM molecules and conversely how mutations in genes encoding ECM components trigger accumulation of oxidative stress and DNA damage. Both situations hamper the reestablishment of cell and tissue homeostasis, with negative impacts on tissue and organ function, which can be a driver for severe pathological conditions. |
| first_indexed | 2024-12-22T07:08:33Z |
| format | Article |
| id | doaj.art-0ef403c7e9f04252b6092f50343cdfe9 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-22T07:08:33Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-0ef403c7e9f04252b6092f50343cdfe92022-12-21T18:34:36ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-07-011210.3389/fgene.2021.673002673002Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix ComponentsSusana G. Martins0Susana G. Martins1Rita Zilhão2Rita Zilhão3Sólveig Thorsteinsdóttir4Sólveig Thorsteinsdóttir5Ana Rita Carlos6Ana Rita Carlos7Centro de Ecologia, Evolução e Alterações Ambientais, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalDepartamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalCentro de Ecologia, Evolução e Alterações Ambientais, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalDepartamento de Biologia Vegetal, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalCentro de Ecologia, Evolução e Alterações Ambientais, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalDepartamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalCentro de Ecologia, Evolução e Alterações Ambientais, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalDepartamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Lisboa, PortugalCells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function. Oxidative stress, caused by excess ROS, and DNA damage, triggered in response to different sources, are countered and resolved by specific mechanisms, allowing the normal physiological equilibrium of cells and tissues to be restored. One process that is affected by oxidative stress and DNA damage is extracellular matrix (ECM) remodeling, which is a continuous and highly controlled mechanism that allows tissues to readjust in reaction to different challenges. The crosstalk between oxidative stress/DNA damage and ECM remodeling is not unidirectional. Quite on the contrary, mutations in ECM genes have a strong impact on tissue homeostasis and are characterized by increased oxidative stress and potentially also accumulation of DNA damage. In this review, we will discuss how oxidative stress and DNA damage affect the expression and deposition of ECM molecules and conversely how mutations in genes encoding ECM components trigger accumulation of oxidative stress and DNA damage. Both situations hamper the reestablishment of cell and tissue homeostasis, with negative impacts on tissue and organ function, which can be a driver for severe pathological conditions.https://www.frontiersin.org/articles/10.3389/fgene.2021.673002/fulloxidative stressDNA damageECM remodelingtissue homeostasisECM gene expression |
| spellingShingle | Susana G. Martins Susana G. Martins Rita Zilhão Rita Zilhão Sólveig Thorsteinsdóttir Sólveig Thorsteinsdóttir Ana Rita Carlos Ana Rita Carlos Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components Frontiers in Genetics oxidative stress DNA damage ECM remodeling tissue homeostasis ECM gene expression |
| title | Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components |
| title_full | Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components |
| title_fullStr | Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components |
| title_full_unstemmed | Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components |
| title_short | Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extracellular Matrix Components |
| title_sort | linking oxidative stress and dna damage to changes in the expression of extracellular matrix components |
| topic | oxidative stress DNA damage ECM remodeling tissue homeostasis ECM gene expression |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2021.673002/full |
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