A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog
Abstract Background Heart tumors are rare in dogs. They can be benign or malignant. Clinical signs depend primarily on the location of the tumor and its effect on blood flow. Case presentation An eleven-year-old crossbreed male dog lethargic and anorectic for previous 3 days was presented to the vet...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-023-03701-5 |
| _version_ | 1797452215711956992 |
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| author | Olga Szaluś-Jordanow Michał Czopowicz Agata Moroz-Fik Marcin Mickiewicz Andrzej Łobaczewski Sylwia Tarka Łukasz Koperski Rafał Sapierzyński |
| author_facet | Olga Szaluś-Jordanow Michał Czopowicz Agata Moroz-Fik Marcin Mickiewicz Andrzej Łobaczewski Sylwia Tarka Łukasz Koperski Rafał Sapierzyński |
| author_sort | Olga Szaluś-Jordanow |
| collection | DOAJ |
| description | Abstract Background Heart tumors are rare in dogs. They can be benign or malignant. Clinical signs depend primarily on the location of the tumor and its effect on blood flow. Case presentation An eleven-year-old crossbreed male dog lethargic and anorectic for previous 3 days was presented to the veterinary clinic. The focused ultrasound assessment with sonograms in trauma (FAST) revealed multiple tumors in the heart which were then confirmed in echocardiographic examination performed by a veterinary cardiologist. Due to the poor general condition and grave prognosis, the dog was humanely euthanized. The autopsy revealed numerous intracardiac tumors in all four heart chambers. No proliferative changes were found in other organs either in thoracic or abdominal cavity. Immunohistochemical examination was performed using formalin-fixed, paraffin-embedded tissue from heart masses. The antibodies against myoglobin, desmin, smooth muscle actin, vimentin, CD34, S100, and pan-cytokeratin (AE1/AE3) were used. Microscopically, the tumor was composed of fascicles of spindle-shaped cells with pale eosinophilic cytoplasm with round, oval, and focally elongated nuclei and one or two prominent nucleoli. The tumor cells showed strong diffuse cytoplasmic immunopositivity for myoglobin and vimentin and focal staining for desmin. Immunostainings for smooth muscle actin-SMA, CD34, pan-cytokeratin, S-100 protein were negative. The immunohistochemical staining pattern confirmed rhabdomyosarcoma. Conclusions This is the first description of the primary multiple heart rhabdomyosarcoma in a dog. |
| first_indexed | 2024-03-09T15:05:34Z |
| format | Article |
| id | doaj.art-0efa8e7194634e00baa31841134c4cac |
| institution | Directory Open Access Journal |
| issn | 1746-6148 |
| language | English |
| last_indexed | 2024-03-09T15:05:34Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj.art-0efa8e7194634e00baa31841134c4cac2023-11-26T13:37:59ZengBMCBMC Veterinary Research1746-61482023-08-011911810.1186/s12917-023-03701-5A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dogOlga Szaluś-Jordanow0Michał Czopowicz1Agata Moroz-Fik2Marcin Mickiewicz3Andrzej Łobaczewski4Sylwia Tarka5Łukasz Koperski6Rafał Sapierzyński7Department of Small Animal Diseases with Clinic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWDivision of Veterinary Epidemiology and Economics, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWVeterinary Clinic AuxiliumDepartment of Forensic Medicine, Medical University of WarsawDepartment of Pathology, Medical University of WarsawDepartment of Pathology and Veterinary Diagnostic, Institute of Veterinary Medicine, Warsaw University of Life Sciences-SGGWAbstract Background Heart tumors are rare in dogs. They can be benign or malignant. Clinical signs depend primarily on the location of the tumor and its effect on blood flow. Case presentation An eleven-year-old crossbreed male dog lethargic and anorectic for previous 3 days was presented to the veterinary clinic. The focused ultrasound assessment with sonograms in trauma (FAST) revealed multiple tumors in the heart which were then confirmed in echocardiographic examination performed by a veterinary cardiologist. Due to the poor general condition and grave prognosis, the dog was humanely euthanized. The autopsy revealed numerous intracardiac tumors in all four heart chambers. No proliferative changes were found in other organs either in thoracic or abdominal cavity. Immunohistochemical examination was performed using formalin-fixed, paraffin-embedded tissue from heart masses. The antibodies against myoglobin, desmin, smooth muscle actin, vimentin, CD34, S100, and pan-cytokeratin (AE1/AE3) were used. Microscopically, the tumor was composed of fascicles of spindle-shaped cells with pale eosinophilic cytoplasm with round, oval, and focally elongated nuclei and one or two prominent nucleoli. The tumor cells showed strong diffuse cytoplasmic immunopositivity for myoglobin and vimentin and focal staining for desmin. Immunostainings for smooth muscle actin-SMA, CD34, pan-cytokeratin, S-100 protein were negative. The immunohistochemical staining pattern confirmed rhabdomyosarcoma. Conclusions This is the first description of the primary multiple heart rhabdomyosarcoma in a dog.https://doi.org/10.1186/s12917-023-03701-5RhabdomyosarcomaHeartNeoplasmsDogEchocardiography |
| spellingShingle | Olga Szaluś-Jordanow Michał Czopowicz Agata Moroz-Fik Marcin Mickiewicz Andrzej Łobaczewski Sylwia Tarka Łukasz Koperski Rafał Sapierzyński A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog BMC Veterinary Research Rhabdomyosarcoma Heart Neoplasms Dog Echocardiography |
| title | A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| title_full | A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| title_fullStr | A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| title_full_unstemmed | A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| title_short | A primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| title_sort | primary multiple pleomorphic rhabdomyosarcoma of the heart in an adult dog |
| topic | Rhabdomyosarcoma Heart Neoplasms Dog Echocardiography |
| url | https://doi.org/10.1186/s12917-023-03701-5 |
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