Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity
Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has spe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/4/666 |
| _version_ | 1827656311005773824 |
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| author | Lijun Ge Shuyuan Liu Limor Rubin Philip Lazarovici Wenhua Zheng |
| author_facet | Lijun Ge Shuyuan Liu Limor Rubin Philip Lazarovici Wenhua Zheng |
| author_sort | Lijun Ge |
| collection | DOAJ |
| description | Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has specific endocrine roles in the CNS, the concept is emerging that IGF-I might be also important in disorders such as ischemic stroke, brain trauma, Alzheimer’s disease, epilepsy, etc., by inducing neuroprotective effects towards glutamate-mediated excitotoxic signaling pathways. Research in rodent models has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 was administered by different routes, and several clinical studies have shown safety and promise of efficacy in neurological disorders of the CNS. Focusing on the relationship between IGF-1-induced neuroprotection and glutamate-induced excitatory neurotoxicity, this review addresses the research progress in the field, intending to provide a rationale for using IGF-I clinically to confer neuroprotective therapy towards neurological diseases with glutamate excitotoxicity as a common pathological pathway. |
| first_indexed | 2024-03-09T22:19:50Z |
| format | Article |
| id | doaj.art-0efbeeda4d5b4acb93b3e54393f4a6db |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:19:50Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0efbeeda4d5b4acb93b3e54393f4a6db2023-11-23T19:15:01ZengMDPI AGCells2073-44092022-02-0111466610.3390/cells11040666Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced NeurotoxicityLijun Ge0Shuyuan Liu1Limor Rubin2Philip Lazarovici3Wenhua Zheng4Center of Reproduction, Development and Aging Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, ChinaCollege of Life Science, Zhejiang Chinese Medical University, Hangzhou 310053, ChinaAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem 9112001, IsraelPharmacology, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, IsraelCenter of Reproduction, Development and Aging Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, ChinaInsulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has specific endocrine roles in the CNS, the concept is emerging that IGF-I might be also important in disorders such as ischemic stroke, brain trauma, Alzheimer’s disease, epilepsy, etc., by inducing neuroprotective effects towards glutamate-mediated excitotoxic signaling pathways. Research in rodent models has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 was administered by different routes, and several clinical studies have shown safety and promise of efficacy in neurological disorders of the CNS. Focusing on the relationship between IGF-1-induced neuroprotection and glutamate-induced excitatory neurotoxicity, this review addresses the research progress in the field, intending to provide a rationale for using IGF-I clinically to confer neuroprotective therapy towards neurological diseases with glutamate excitotoxicity as a common pathological pathway.https://www.mdpi.com/2073-4409/11/4/666glutamate-mediated excitotoxicitysignaling pathwaysinsulin-like growth factor-1neuroprotectionanimal modelsclinical trials |
| spellingShingle | Lijun Ge Shuyuan Liu Limor Rubin Philip Lazarovici Wenhua Zheng Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity Cells glutamate-mediated excitotoxicity signaling pathways insulin-like growth factor-1 neuroprotection animal models clinical trials |
| title | Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity |
| title_full | Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity |
| title_fullStr | Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity |
| title_full_unstemmed | Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity |
| title_short | Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity |
| title_sort | research progress on neuroprotection of insulin like growth factor 1 towards glutamate induced neurotoxicity |
| topic | glutamate-mediated excitotoxicity signaling pathways insulin-like growth factor-1 neuroprotection animal models clinical trials |
| url | https://www.mdpi.com/2073-4409/11/4/666 |
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