Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity

Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity

Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has spe...

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Bibliographic Details
Main Authors: Lijun Ge, Shuyuan Liu, Limor Rubin, Philip Lazarovici, Wenhua Zheng
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
glutamate-mediated excitotoxicity
signaling pathways
insulin-like growth factor-1
neuroprotection
animal models
clinical trials
Online Access:https://www.mdpi.com/2073-4409/11/4/666

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