Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs

How mammalian tissues maintain their architecture and tissue-specificity is poorly understood. Previously, we documented both the indispensable role of the extracellular matrix (ECM) protein, laminin-111 (LN1), in the formation of normal breast acini, and the phenotypic reversion of cancer cells to...

Full description

Bibliographic Details
Main Authors: Saori Furuta, Gang Ren, Jian-Hua Mao, Mina J Bissell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
extracellular matrix
mammary morphogenesis
tumor cell reversion
laminins
nitric oxide
p53
Online Access:https://elifesciences.org/articles/26148

Similar Items

Similar Items