Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation

Inflammatory activation of endothelial cells increases glycolysis and oxygen consumption despite inhibiting cell proliferation

Endothelial cell function and metabolism are closely linked to differential use of energy substrate sources and combustion. While endothelial cell migration is promoted by 2‐phosphofructokinase‐6/fructose‐2,6‐bisphosphatase (PFKFB3)‐driven glycolysis, proliferation also depends on fatty acid oxidati...

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Bibliographic Details
Main Authors: Jonas Aakre Wik, Danh Phung, Shrikant Kolan, Guttorm Haraldsen, Bjørn Steen Skålhegg, Johanna Hol Fosse
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:FEBS Open Bio
Subjects:
endothelial cells
glycolysis
IL‐1β
inflammation
metabolism
Online Access:https://doi.org/10.1002/2211-5463.13174

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