Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma

Single-cell transcriptomics reveals the role of Macrophage-Naïve CD4 + T cell interaction in the immunosuppressive microenvironment of primary liver carcinoma

Abstract Background Liver carcinoma generally presents as an immunosuppressive microenvironment that promotes tumor evasion. The intercellular crosstalk of immune cells significantly influences the construction of an immunosuppressive microenvironment. This study aimed to investigate the important i...

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Bibliographic Details
Main Authors: Zhuomao Mo, Daiyuan Liu, Yihan Chen, Jin Luo, Wenjing Li, Jiahui Liu, Ling Yu, Bijun Huang, Shijun Zhang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Translational Medicine
Subjects:
Single cell transcriptomic
Macrophage
Naïve CD4 + T cell
Tumor microenvironment
Immunosuppression
Online Access:https://doi.org/10.1186/s12967-022-03675-2

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