Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally
In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hem...
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| Format: | Article |
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MDPI AG
2019-04-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/9/5/98 |
| _version_ | 1818391335516766208 |
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| author | Soumya Ghosh David Hathorn Jennifer Eisenhauer Jesse Dixon Ian D. Cooper |
| author_facet | Soumya Ghosh David Hathorn Jennifer Eisenhauer Jesse Dixon Ian D. Cooper |
| author_sort | Soumya Ghosh |
| collection | DOAJ |
| description | In many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes. |
| first_indexed | 2024-12-14T05:11:53Z |
| format | Article |
| id | doaj.art-0f00e82ee18d450e9c0cb1c8630e137b |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-12-14T05:11:53Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0f00e82ee18d450e9c0cb1c8630e137b2022-12-21T23:15:56ZengMDPI AGBrain Sciences2076-34252019-04-01959810.3390/brainsci9050098brainsci9050098Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability BilaterallySoumya Ghosh0David Hathorn1Jennifer Eisenhauer2Jesse Dixon3Ian D. Cooper4Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, AustraliaCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, AustraliaCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, AustraliaCentre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science, University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, AustraliaDepartment of Physiotherapy, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA 6009, AustraliaIn many studies, anodal transcranial Direct Current Stimulation (tDCS) is applied near the vertex to simultaneously facilitate leg motor cortex (M1) of both hemispheres and enhance recovery of gait and balance in neurological disorders. However, its effect on the excitability of leg M1 in either hemisphere is not well known. In this double-blind sham-controlled study, corticospinal excitability changes induced in leg M1 of both hemispheres by anodal (2 mA for 20 minutes) or sham tDCS (for 20 min) over the vertex were evaluated. Peak amplitudes of Transcranial Magnetic Stimulation (TMS) induced motor evoked potentials (MEPs) were measured over the contralateral Tibialis Anterior (TA) muscle before and up to 40 min after tDCS in 11 normal participants. Analysis of data from all participants found significant overall increase in the excitability of leg M1 after tDCS. However, in individual subjects there was variability in observed effects. In 4 participants, 20 min of tDCS increased mean MEPs of TAs on both sides; in 4 participants there was increased mean MEP only on one side and in 3 subjects there was no change. It’s not known if the benefits of tDCS in improving gait and balance are dependent on excitability changes induced in one or both leg M1; such information may be useful to predict treatment outcomes.https://www.mdpi.com/2076-3425/9/5/98transcranial direct current stimulationleg motor cortexcorticospinal excitability |
| spellingShingle | Soumya Ghosh David Hathorn Jennifer Eisenhauer Jesse Dixon Ian D. Cooper Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally Brain Sciences transcranial direct current stimulation leg motor cortex corticospinal excitability |
| title | Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally |
| title_full | Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally |
| title_fullStr | Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally |
| title_full_unstemmed | Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally |
| title_short | Anodal Transcranial Direct Current Stimulation over the Vertex Enhances Leg Motor Cortex Excitability Bilaterally |
| title_sort | anodal transcranial direct current stimulation over the vertex enhances leg motor cortex excitability bilaterally |
| topic | transcranial direct current stimulation leg motor cortex corticospinal excitability |
| url | https://www.mdpi.com/2076-3425/9/5/98 |
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