Identification of a Tumor Cell Associated Type I IFN Resistance Gene Expression Signature of Human Melanoma, the Components of Which Have a Predictive Potential for Immunotherapy

Identification of a Tumor Cell Associated Type I IFN Resistance Gene Expression Signature of Human Melanoma, the Components of Which Have a Predictive Potential for Immunotherapy

We developed a human melanoma model using the HT168-M1 cell line to induce IFN-α2 resistance in vitro (HT168-M1res), which was proven to be maintained in vivo in SCID mice. Comparing the mRNA profile of in vitro cultured HT168-M1res cells to its sensitive counterpart, we found 79 differentially expr...

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Bibliographic Details
Main Authors: Andrea Ladányi, Erzsébet Rásó, Tamás Barbai, Laura Vízkeleti, László G. Puskás, Szonja A. Kovács, Balázs Győrffy, József Tímár
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
human melanoma
preclinical model
type I interferon resistance
gene expression
immunotherapy resistance
Online Access:https://www.mdpi.com/1422-0067/23/5/2704

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