Air pollution, metabolites and respiratory health across the life-course
Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summa...
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2022-08-01
|
| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/31/165/220038.full |
| _version_ | 1811264431127003136 |
|---|---|
| author | Olena Gruzieva Ayoung Jeong Shizhen He Zhebin Yu Jeroen de Bont Maria G.M. Pinho Ikenna C. Eze Sara Kress Craig E. Wheelock Annette Peters Jelle Vlaanderen Kees de Hoogh Augustin Scalbert Marc Chadeau-Hyam Roel C.H. Vermeulen Ulrike Gehring Nicole Probst-Hensch Erik Melén |
| author_facet | Olena Gruzieva Ayoung Jeong Shizhen He Zhebin Yu Jeroen de Bont Maria G.M. Pinho Ikenna C. Eze Sara Kress Craig E. Wheelock Annette Peters Jelle Vlaanderen Kees de Hoogh Augustin Scalbert Marc Chadeau-Hyam Roel C.H. Vermeulen Ulrike Gehring Nicole Probst-Hensch Erik Melén |
| author_sort | Olena Gruzieva |
| collection | DOAJ |
| description | Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data. |
| first_indexed | 2024-04-12T20:04:10Z |
| format | Article |
| id | doaj.art-0f013466235e4ad784236ed28f3a588e |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-12T20:04:10Z |
| publishDate | 2022-08-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-0f013466235e4ad784236ed28f3a588e2022-12-22T03:18:27ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172022-08-013116510.1183/16000617.0038-20220038-2022Air pollution, metabolites and respiratory health across the life-courseOlena Gruzieva0Ayoung Jeong1Shizhen He2Zhebin Yu3Jeroen de Bont4Maria G.M. Pinho5Ikenna C. Eze6Sara Kress7Craig E. Wheelock8Annette Peters9Jelle Vlaanderen10Kees de Hoogh11Augustin Scalbert12Marc Chadeau-Hyam13Roel C.H. Vermeulen14Ulrike Gehring15Nicole Probst-Hensch16Erik Melén17 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Swiss Tropical and Public Health Institute, Basel, Switzerland Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Dept of Epidemiology and Data Science, Amsterdam Public Health, Amsterdam UMC, location VUmc, Amsterdam, The Netherlands Swiss Tropical and Public Health Institute, Basel, Switzerland IUF-Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Institute of Epidemiology, Helmholz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Swiss Tropical and Public Health Institute, Basel, Switzerland Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands Swiss Tropical and Public Health Institute, Basel, Switzerland Dept of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data.http://err.ersjournals.com/content/31/165/220038.full |
| spellingShingle | Olena Gruzieva Ayoung Jeong Shizhen He Zhebin Yu Jeroen de Bont Maria G.M. Pinho Ikenna C. Eze Sara Kress Craig E. Wheelock Annette Peters Jelle Vlaanderen Kees de Hoogh Augustin Scalbert Marc Chadeau-Hyam Roel C.H. Vermeulen Ulrike Gehring Nicole Probst-Hensch Erik Melén Air pollution, metabolites and respiratory health across the life-course European Respiratory Review |
| title | Air pollution, metabolites and respiratory health across the life-course |
| title_full | Air pollution, metabolites and respiratory health across the life-course |
| title_fullStr | Air pollution, metabolites and respiratory health across the life-course |
| title_full_unstemmed | Air pollution, metabolites and respiratory health across the life-course |
| title_short | Air pollution, metabolites and respiratory health across the life-course |
| title_sort | air pollution metabolites and respiratory health across the life course |
| url | http://err.ersjournals.com/content/31/165/220038.full |
| work_keys_str_mv | AT olenagruzieva airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT ayoungjeong airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT shizhenhe airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT zhebinyu airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT jeroendebont airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT mariagmpinho airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT ikennaceze airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT sarakress airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT craigewheelock airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT annettepeters airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT jellevlaanderen airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT keesdehoogh airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT augustinscalbert airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT marcchadeauhyam airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT roelchvermeulen airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT ulrikegehring airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT nicoleprobsthensch airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse AT erikmelen airpollutionmetabolitesandrespiratoryhealthacrossthelifecourse |