Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data

Quantifying Glioblastoma Drug Response Dynamics Incorporating Treatment Sensitivity and Blood Brain Barrier Penetrance From Experimental Data

Many drugs investigated for the treatment of glioblastoma (GBM) have had disappointing clinical trial results. Efficacy of these agents is dependent on adequate delivery to sensitive tumor cell populations, which is limited by the blood-brain barrier (BBB). Additionally, tumor heterogeneity can lead...

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Bibliographic Details
Main Authors: Susan Christine Massey, Javier C. Urcuyo, Bianca Maria Marin, Jann N. Sarkaria, Kristin R. Swanson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
glioblastoma
blood–brain barrier
drug sensitivity
epidermal growth factor receptor (EGFR)
parameter estimation
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00830/full

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