Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel

Dimeric Tubulin Modifies Mechanical Properties of Lipid Bilayer, as Probed Using Gramicidin A Channel

Using the gramicidin A channel as a molecular probe, we show that tubulin binding to planar lipid membranes changes the channel kinetics—seen as an increase in the lifetime of the channel dimer—and thus points towards modification of the membrane’s mechanical properties. The effect is more pronounce...

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Bibliographic Details
Main Authors: Tatiana K. Rostovtseva, Michael Weinrich, Daniel Jacobs, William M. Rosencrans, Sergey M. Bezrukov
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
amphitropic proteins
protein–lipid interactions
non-lamellar lipids
lipid packing stress
planar lipid membranes
Online Access:https://www.mdpi.com/1422-0067/25/4/2204

Internet

https://www.mdpi.com/1422-0067/25/4/2204

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