A dynamic model of hepatitis B virus with drug-resistant treatment
In this paper, the problem of reducing the effectiveness of drug resistance treatment due to mutation of hepatitis B virus is investigated, a model of hepatitis B virus with drug resistance treatment is established, and the existence conditions of four equilibrium points in the model are provided. T...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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AIMS Press
2020-06-01
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| Series: | AIMS Mathematics |
| Subjects: | |
| Online Access: | https://www.aimspress.com/article/10.3934/math.2020303/fulltext.html |
| _version_ | 1818259528068628480 |
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| author | Dong-Mei Li Bing Chai |
| author_facet | Dong-Mei Li Bing Chai |
| author_sort | Dong-Mei Li |
| collection | DOAJ |
| description | In this paper, the problem of reducing the effectiveness of drug resistance treatment due to mutation of hepatitis B virus is investigated, a model of hepatitis B virus with drug resistance treatment is established, and the existence conditions of four equilibrium points in the model are provided. The effect of drug resistance caused by virus mutation on drug treatment is simulated. It is found that drug efficacy decreases with the increase in mutation rate. Without considering the value of mutation rate, the continuous usage of drugs can meet the clinical treatment standard, while stopping treatment will cause the virus to rebound. |
| first_indexed | 2024-12-12T18:16:52Z |
| format | Article |
| id | doaj.art-0f032e2860254073b10d26e0db995f26 |
| institution | Directory Open Access Journal |
| issn | 2473-6988 |
| language | English |
| last_indexed | 2024-12-12T18:16:52Z |
| publishDate | 2020-06-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | AIMS Mathematics |
| spelling | doaj.art-0f032e2860254073b10d26e0db995f262022-12-22T00:16:14ZengAIMS PressAIMS Mathematics2473-69882020-06-01554734475310.3934/math.2020303A dynamic model of hepatitis B virus with drug-resistant treatmentDong-Mei Li0Bing Chai1College of Science, Harbin University of Science and Technology, Harbin 150080, ChinaCollege of Science, Harbin University of Science and Technology, Harbin 150080, ChinaIn this paper, the problem of reducing the effectiveness of drug resistance treatment due to mutation of hepatitis B virus is investigated, a model of hepatitis B virus with drug resistance treatment is established, and the existence conditions of four equilibrium points in the model are provided. The effect of drug resistance caused by virus mutation on drug treatment is simulated. It is found that drug efficacy decreases with the increase in mutation rate. Without considering the value of mutation rate, the continuous usage of drugs can meet the clinical treatment standard, while stopping treatment will cause the virus to rebound.https://www.aimspress.com/article/10.3934/math.2020303/fulltext.htmldrug resistancedynamics model of hepatitis b virusequilibrium pointstabilitynumerical simulation |
| spellingShingle | Dong-Mei Li Bing Chai A dynamic model of hepatitis B virus with drug-resistant treatment AIMS Mathematics drug resistance dynamics model of hepatitis b virus equilibrium point stability numerical simulation |
| title | A dynamic model of hepatitis B virus with drug-resistant treatment |
| title_full | A dynamic model of hepatitis B virus with drug-resistant treatment |
| title_fullStr | A dynamic model of hepatitis B virus with drug-resistant treatment |
| title_full_unstemmed | A dynamic model of hepatitis B virus with drug-resistant treatment |
| title_short | A dynamic model of hepatitis B virus with drug-resistant treatment |
| title_sort | dynamic model of hepatitis b virus with drug resistant treatment |
| topic | drug resistance dynamics model of hepatitis b virus equilibrium point stability numerical simulation |
| url | https://www.aimspress.com/article/10.3934/math.2020303/fulltext.html |
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