Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls
Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has not been an objective diagnostic biomarker. Re...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/148 |
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| author | Mohamed B. Abou-Donia Maxine H. Krengel Elizabeth S. Lapadula Clara G. Zundel Jessica LeClair Joseph Massaro Emily Quinn Lisa A. Conboy Efi Kokkotou Daniel D. Nguyen Maria Abreu Nancy G. Klimas Kimberly Sullivan |
| author_facet | Mohamed B. Abou-Donia Maxine H. Krengel Elizabeth S. Lapadula Clara G. Zundel Jessica LeClair Joseph Massaro Emily Quinn Lisa A. Conboy Efi Kokkotou Daniel D. Nguyen Maria Abreu Nancy G. Klimas Kimberly Sullivan |
| author_sort | Mohamed B. Abou-Donia |
| collection | DOAJ |
| description | Veterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has not been an objective diagnostic biomarker. Recently, we reported on a newly developed blood biomarker that discriminates GWI from GW healthy controls, and symptomatic controls with irritable bowel syndrome (IBS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was designed to compare levels of these biomarkers between men and women with GWI, as well as sex-specific effects in comparison to healthy GW veterans and symptomatic controls (IBS, ME/CFS). The results showed that men and women with GWI differ in 2 of 10 plasma autoantibodies, with men showing significantly elevated levels. Men and women with GWI showed significantly different levels of autoantibodies in 8 of 10 biomarkers to neuronal and glial proteins in plasma relative to controls. In summary, the present study addressed the utility of the use of plasma autoantibodies for CNS proteins to distinguish among both men and women veterans with GWI and other healthy and symptomatic control groups. |
| first_indexed | 2024-03-09T03:54:05Z |
| format | Article |
| id | doaj.art-0f03f324f06d47a29dc6c0f9b2f72b32 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T03:54:05Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-0f03f324f06d47a29dc6c0f9b2f72b322023-12-03T14:23:18ZengMDPI AGBrain Sciences2076-34252021-01-0111214810.3390/brainsci11020148Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic ControlsMohamed B. Abou-Donia0Maxine H. Krengel1Elizabeth S. Lapadula2Clara G. Zundel3Jessica LeClair4Joseph Massaro5Emily Quinn6Lisa A. Conboy7Efi Kokkotou8Daniel D. Nguyen9Maria Abreu10Nancy G. Klimas11Kimberly Sullivan12Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USADepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USADepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USADepartment of Neurology, Boston University School of Medicine, Boston, MA 02118, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USADepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USADepartment of Medicine, Harvard Medical School, Boston, MA 02115, USADepartment of Medicine, Harvard Medical School, Boston, MA 02115, USADepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USADr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USADr. Kiran C. Patel College of Osteopathic Medicine, Institute for Neuroimmune Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USADepartment of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USAVeterans from the 1991 Gulf War (GW) have suffered from Gulf War illness (GWI) for nearly 30 years. This illness encompasses multiple body systems, including the central nervous system (CNS). Diagnosis and treatment of GWI is difficult because there has not been an objective diagnostic biomarker. Recently, we reported on a newly developed blood biomarker that discriminates GWI from GW healthy controls, and symptomatic controls with irritable bowel syndrome (IBS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The present study was designed to compare levels of these biomarkers between men and women with GWI, as well as sex-specific effects in comparison to healthy GW veterans and symptomatic controls (IBS, ME/CFS). The results showed that men and women with GWI differ in 2 of 10 plasma autoantibodies, with men showing significantly elevated levels. Men and women with GWI showed significantly different levels of autoantibodies in 8 of 10 biomarkers to neuronal and glial proteins in plasma relative to controls. In summary, the present study addressed the utility of the use of plasma autoantibodies for CNS proteins to distinguish among both men and women veterans with GWI and other healthy and symptomatic control groups.https://www.mdpi.com/2076-3425/11/2/148CNS autoantibodyGulf War illnessgenderbiomarkersproteinsmyalgic encephalomyelitis/chronic fatigue syndrome |
| spellingShingle | Mohamed B. Abou-Donia Maxine H. Krengel Elizabeth S. Lapadula Clara G. Zundel Jessica LeClair Joseph Massaro Emily Quinn Lisa A. Conboy Efi Kokkotou Daniel D. Nguyen Maria Abreu Nancy G. Klimas Kimberly Sullivan Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls Brain Sciences CNS autoantibody Gulf War illness gender biomarkers proteins myalgic encephalomyelitis/chronic fatigue syndrome |
| title | Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls |
| title_full | Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls |
| title_fullStr | Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls |
| title_full_unstemmed | Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls |
| title_short | Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls |
| title_sort | sex based differences in plasma autoantibodies to central nervous system proteins in gulf war veterans versus healthy and symptomatic controls |
| topic | CNS autoantibody Gulf War illness gender biomarkers proteins myalgic encephalomyelitis/chronic fatigue syndrome |
| url | https://www.mdpi.com/2076-3425/11/2/148 |
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