Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke

Adenosine A1R/A3R agonist AST-004 reduces brain infarction in mouse and rat models of acute ischemic stroke

Acute ischemic stroke (AIS) is the second leading cause of death globally. No Food and Drug Administration (FDA) approved therapies exist that target cerebroprotection following stroke. Our group recently reported significant cerebroprotection with the adenosine A1/A3 receptor agonist, AST-004, in a...

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Bibliographic Details
Main Authors: Elizabeth S. Fisher, Yanan Chen, Mikaela M. Sifuentes, Jeremy J. Stubblefield, Damian Lozano, Deborah M. Holstein, JingMei Ren, Matthew Davenport, Nicholas DeRosa, Tsung-pei Chen, Gerard Nickel, Theodore E. Liston, James D. Lechleiter
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Stroke
Subjects:
Adora3
stroke treatment
mitochondrial metabolism
ATP
astrocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fstro.2022.1010928/full

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