Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis
Gastrointestinal involvement is a common clinical feature of patients with systemic amyloidosis. This condition is responsible for invalidating gastrointestinal symptoms, a significant macro and micronutrient deficit, and is a marker of disease severity. Gastrointestinal involvement should be active...
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/2/528 |
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| author | Francesca Dongiglio Emanuele Monda Giuseppe Palmiero Federica Verrillo Marta Rubino Gaetano Diana Annapaola Cirillo Adelaide Fusco Erica Vetrano Michele Lioncino Martina Caiazza Giuseppe Cerciello Laura Capodicasa Flavia Chiosi Vincenzo Simonelli Maria Luisa De Rimini Francesco Natale Alessandro Di Santo Elisabetta Moscarella Paolo Calabrò Giuseppe Limongelli |
| author_facet | Francesca Dongiglio Emanuele Monda Giuseppe Palmiero Federica Verrillo Marta Rubino Gaetano Diana Annapaola Cirillo Adelaide Fusco Erica Vetrano Michele Lioncino Martina Caiazza Giuseppe Cerciello Laura Capodicasa Flavia Chiosi Vincenzo Simonelli Maria Luisa De Rimini Francesco Natale Alessandro Di Santo Elisabetta Moscarella Paolo Calabrò Giuseppe Limongelli |
| author_sort | Francesca Dongiglio |
| collection | DOAJ |
| description | Gastrointestinal involvement is a common clinical feature of patients with systemic amyloidosis. This condition is responsible for invalidating gastrointestinal symptoms, a significant macro and micronutrient deficit, and is a marker of disease severity. Gastrointestinal involvement should be actively sought in patients with systemic amyloidosis, while its diagnosis is challenging in patients with isolated gastrointestinal symptoms. The nutritional status in systemic amyloidosis plays an essential role in the clinical course and is considered a significant prognostic factor. However, the definition of nutritional status is still challenging due to the lack of internationally accepted thresholds for anthropometric and biochemical variables, especially in specific populations such as those with systemic amyloidosis. This review aims to elucidate the fundamental steps for nutritional assessment by using clinical and instrumental tools for better prognostic stratification and patient management regarding quality of life and outcomes. |
| first_indexed | 2024-03-09T12:11:21Z |
| format | Article |
| id | doaj.art-0f04503129df440f90a54a7e46009b15 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T12:11:21Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0f04503129df440f90a54a7e46009b152023-11-30T22:51:11ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112252810.3390/jcm12020528Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic AmyloidosisFrancesca Dongiglio0Emanuele Monda1Giuseppe Palmiero2Federica Verrillo3Marta Rubino4Gaetano Diana5Annapaola Cirillo6Adelaide Fusco7Erica Vetrano8Michele Lioncino9Martina Caiazza10Giuseppe Cerciello11Laura Capodicasa12Flavia Chiosi13Vincenzo Simonelli14Maria Luisa De Rimini15Francesco Natale16Alessandro Di Santo17Elisabetta Moscarella18Paolo Calabrò19Giuseppe Limongelli20Inherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyHaematology Unit, Department of Clinical Medicine and Surgery, University of Naples “Federico II”, Via S. Pansini, 80131 Naples, ItalyDepartment of Nephrology, Monaldi Hospital, Via L. Bianchi, 80131 Naples, ItalyDepartment of Ophthalmology, Monaldi Hospital, Via L. Bianchi, 80131 Naples, ItalyDepartment of Neurology, Monaldi Hospital, Via L. Bianchi, 80131 Naples, ItalyDepartment of Nuclear Medicine, Monaldi Hospital, Via L. Bianchi, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyNeMO-Napoli Clinical Center for Neuromuscular Diseases, Monaldi Hospital, Via L. Bianchi, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyInherited and Rare Cardiovascular Diseases, Department of Translational Medical Sciences, University of Campania “Luigi Vanvitelli”, Monaldi Hospital, 80131 Naples, ItalyGastrointestinal involvement is a common clinical feature of patients with systemic amyloidosis. This condition is responsible for invalidating gastrointestinal symptoms, a significant macro and micronutrient deficit, and is a marker of disease severity. Gastrointestinal involvement should be actively sought in patients with systemic amyloidosis, while its diagnosis is challenging in patients with isolated gastrointestinal symptoms. The nutritional status in systemic amyloidosis plays an essential role in the clinical course and is considered a significant prognostic factor. However, the definition of nutritional status is still challenging due to the lack of internationally accepted thresholds for anthropometric and biochemical variables, especially in specific populations such as those with systemic amyloidosis. This review aims to elucidate the fundamental steps for nutritional assessment by using clinical and instrumental tools for better prognostic stratification and patient management regarding quality of life and outcomes.https://www.mdpi.com/2077-0383/12/2/528amyloidosisgastrointestinal disordersprognosisnutritional assessment |
| spellingShingle | Francesca Dongiglio Emanuele Monda Giuseppe Palmiero Federica Verrillo Marta Rubino Gaetano Diana Annapaola Cirillo Adelaide Fusco Erica Vetrano Michele Lioncino Martina Caiazza Giuseppe Cerciello Laura Capodicasa Flavia Chiosi Vincenzo Simonelli Maria Luisa De Rimini Francesco Natale Alessandro Di Santo Elisabetta Moscarella Paolo Calabrò Giuseppe Limongelli Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis Journal of Clinical Medicine amyloidosis gastrointestinal disorders prognosis nutritional assessment |
| title | Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis |
| title_full | Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis |
| title_fullStr | Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis |
| title_full_unstemmed | Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis |
| title_short | Pathophysiology, Functional Assessment and Prognostic Implications of Nutritional Disorders in Systemic Amyloidosis |
| title_sort | pathophysiology functional assessment and prognostic implications of nutritional disorders in systemic amyloidosis |
| topic | amyloidosis gastrointestinal disorders prognosis nutritional assessment |
| url | https://www.mdpi.com/2077-0383/12/2/528 |
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