Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study
Background: Differences in response to PRP (platelet-rich plasma) therapy may be linked to the variability of growth factors and their receptor’s genes. Considering that, we checked whether the platelet-derived growth factor receptor beta gene (<i>PDGFRB</i>) single nucleotide polymorphi...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/21/6362 |
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| author | Karol Szyluk Alicja Jarosz Anna Balcerzyk-Matić Joanna Iwanicka Tomasz Iwanicki Tomasz Nowak Marcin Gierek Marius Negru Marcin Kalita Sylwia Górczyńska-Kosiorz Wojciech Kania Paweł Niemiec |
| author_facet | Karol Szyluk Alicja Jarosz Anna Balcerzyk-Matić Joanna Iwanicka Tomasz Iwanicki Tomasz Nowak Marcin Gierek Marius Negru Marcin Kalita Sylwia Górczyńska-Kosiorz Wojciech Kania Paweł Niemiec |
| author_sort | Karol Szyluk |
| collection | DOAJ |
| description | Background: Differences in response to PRP (platelet-rich plasma) therapy may be linked to the variability of growth factors and their receptor’s genes. Considering that, we checked whether the platelet-derived growth factor receptor beta gene (<i>PDGFRB</i>) single nucleotide polymorphisms (SNPs) affect the effectiveness of PRP therapy in treating tennis elbow patients. Methods: The treatment efficacy was analyzed over time (2, 4, 8, 12, 24, 52, and 104 weeks after PRP injection) on 107 patients (132 elbows) using PROMs (patient-reported outcome measures), namely VAS (Visual Analog Scale), QDASH (quick version of Disabilities of the Arm, Shoulder, and Hand) and PRTEE (Patient-Rated Tennis Elbow Evaluation). Five polymorphisms of the <i>PDGFRB</i> gene (rs4324662, rs758588, rs3828610, rs3756311, and rs3756312) were genotyped. Results: The CC (rs3828610) and GG (rs3756311 and rs3756312) genotypes had a particularly strong impact on the effectiveness of the therapy, as measured by the values of PROMs, both in additive as well as dominant/recessive models. These homozygotes were also characterized by significantly higher values of MPV (mean platelet volume). Conclusions: The <i>PDGFRB</i> gene SNPs affect the effectiveness of PRP therapy in treating tennis elbow patients and it may result from the differentiated metabolic activity of platelets in particular genotype variants. |
| first_indexed | 2024-03-09T18:57:22Z |
| format | Article |
| id | doaj.art-0f08fe95250542d5bb34324bf584b290 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T18:57:22Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-0f08fe95250542d5bb34324bf584b2902023-11-24T05:16:27ZengMDPI AGJournal of Clinical Medicine2077-03832022-10-011121636210.3390/jcm11216362Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort StudyKarol Szyluk0Alicja Jarosz1Anna Balcerzyk-Matić2Joanna Iwanicka3Tomasz Iwanicki4Tomasz Nowak5Marcin Gierek6Marius Negru7Marcin Kalita8Sylwia Górczyńska-Kosiorz9Wojciech Kania10Paweł Niemiec11Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia in Katowice, 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandCenter for Burns Treatment, Jana Pawła II Str., 41-100 Siemianowice Śląskie, PolandTrauma and Orthopaedics Department, St. Bernard’s Hospital, Harbour Views Rd., Gibraltar GX11 1AA, UKDistrict Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 Str., 41-940 Piekary Śląskie, PolandDepartment of Internal Medicine, Diabetology and Nephrology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, PolandDepartment of Trauma and Orthopedic Surgery, Multidisciplinary Hospital in Jaworzno, Chełmońskiego 28 Str., 43-600 Jaworzno, PolandDepartment of Biochemistry and Medical Genetics, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Medyków 18 Str., 40-752 Katowice, PolandBackground: Differences in response to PRP (platelet-rich plasma) therapy may be linked to the variability of growth factors and their receptor’s genes. Considering that, we checked whether the platelet-derived growth factor receptor beta gene (<i>PDGFRB</i>) single nucleotide polymorphisms (SNPs) affect the effectiveness of PRP therapy in treating tennis elbow patients. Methods: The treatment efficacy was analyzed over time (2, 4, 8, 12, 24, 52, and 104 weeks after PRP injection) on 107 patients (132 elbows) using PROMs (patient-reported outcome measures), namely VAS (Visual Analog Scale), QDASH (quick version of Disabilities of the Arm, Shoulder, and Hand) and PRTEE (Patient-Rated Tennis Elbow Evaluation). Five polymorphisms of the <i>PDGFRB</i> gene (rs4324662, rs758588, rs3828610, rs3756311, and rs3756312) were genotyped. Results: The CC (rs3828610) and GG (rs3756311 and rs3756312) genotypes had a particularly strong impact on the effectiveness of the therapy, as measured by the values of PROMs, both in additive as well as dominant/recessive models. These homozygotes were also characterized by significantly higher values of MPV (mean platelet volume). Conclusions: The <i>PDGFRB</i> gene SNPs affect the effectiveness of PRP therapy in treating tennis elbow patients and it may result from the differentiated metabolic activity of platelets in particular genotype variants.https://www.mdpi.com/2077-0383/11/21/6362<i>PDGFRB</i>PRPtendinopathytennis elbowSNP |
| spellingShingle | Karol Szyluk Alicja Jarosz Anna Balcerzyk-Matić Joanna Iwanicka Tomasz Iwanicki Tomasz Nowak Marcin Gierek Marius Negru Marcin Kalita Sylwia Górczyńska-Kosiorz Wojciech Kania Paweł Niemiec Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study Journal of Clinical Medicine <i>PDGFRB</i> PRP tendinopathy tennis elbow SNP |
| title | Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study |
| title_full | Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study |
| title_fullStr | Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study |
| title_full_unstemmed | Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study |
| title_short | Polymorphic Variants of the <i>PDGFRB</i> Gene Influence Efficacy of PRP Therapy in Treating Tennis Elbow: A Prospective Cohort Study |
| title_sort | polymorphic variants of the i pdgfrb i gene influence efficacy of prp therapy in treating tennis elbow a prospective cohort study |
| topic | <i>PDGFRB</i> PRP tendinopathy tennis elbow SNP |
| url | https://www.mdpi.com/2077-0383/11/21/6362 |
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