Novel biomarker for predicting sepsis mortality: vitamin D receptor
Objective There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis. Methods This prospective cross-sectional observationa...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-08-01
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| Series: | Journal of International Medical Research |
| Online Access: | https://doi.org/10.1177/03000605211034733 |
| _version_ | 1818646455488872448 |
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| author | Murat Erdoğan Hüseyin Avni Fındıklı |
| author_facet | Murat Erdoğan Hüseyin Avni Fındıklı |
| author_sort | Murat Erdoğan |
| collection | DOAJ |
| description | Objective There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis. Methods This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival. Results The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity. Conclusions VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis. |
| first_indexed | 2024-12-17T00:46:55Z |
| format | Article |
| id | doaj.art-0f0a601e49884c7c9a80040374c12a94 |
| institution | Directory Open Access Journal |
| issn | 1473-2300 |
| language | English |
| last_indexed | 2024-12-17T00:46:55Z |
| publishDate | 2021-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of International Medical Research |
| spelling | doaj.art-0f0a601e49884c7c9a80040374c12a942022-12-21T22:09:52ZengSAGE PublishingJournal of International Medical Research1473-23002021-08-014910.1177/03000605211034733Novel biomarker for predicting sepsis mortality: vitamin D receptorMurat ErdoğanHüseyin Avni FındıklıObjective There are currently no studies on the role of vitamin D receptor (VDR) levels as a cause of or risk factor for sepsis. We aimed to establish the association between VDR levels and 28-day mortality in critically ill patients with sepsis. Methods This prospective cross-sectional observational study included 148 patients diagnosed with sepsis who were treated in the intensive care unit. We measured VDR levels, laboratory characteristics, and health scores and related them to survival. Results The 148 patients included 96 survivors and 52 non-survivors, with VDR levels of 1.92 and 1.36 ng/mL, respectively. Baseline VDR was a significant predictor of 28-day mortality, with an area under the curve of 0.778. A low VDR level was significantly associated with lower overall survival in patients with sepsis according to Kaplan–Meier curve analysis. VDR levels were also negatively correlated with lactate, C-reactive protein, acute physiological and clinical health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores, and disease severity. Conclusions VDR levels were associated with high 28-day mortality and negatively correlated with lactate, C-reactive protein, APACHE II and SOFA scores, and disease severity in patients with sepsis. VDR levels can predict poor outcomes in patients with sepsis.https://doi.org/10.1177/03000605211034733 |
| spellingShingle | Murat Erdoğan Hüseyin Avni Fındıklı Novel biomarker for predicting sepsis mortality: vitamin D receptor Journal of International Medical Research |
| title | Novel biomarker for predicting sepsis mortality: vitamin D receptor |
| title_full | Novel biomarker for predicting sepsis mortality: vitamin D receptor |
| title_fullStr | Novel biomarker for predicting sepsis mortality: vitamin D receptor |
| title_full_unstemmed | Novel biomarker for predicting sepsis mortality: vitamin D receptor |
| title_short | Novel biomarker for predicting sepsis mortality: vitamin D receptor |
| title_sort | novel biomarker for predicting sepsis mortality vitamin d receptor |
| url | https://doi.org/10.1177/03000605211034733 |
| work_keys_str_mv | AT muraterdogan novelbiomarkerforpredictingsepsismortalityvitamindreceptor AT huseyinavnifındıklı novelbiomarkerforpredictingsepsismortalityvitamindreceptor |