Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs
Gold(I) phosphane compounds have recently attracted a renewed interest as potential new protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has been successfully tested against several cancer cell lines and, in particular, against basal-like breast (BLB)...
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MDPI AG
2020-09-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/9/1851 |
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| author | Paola Astolfi Michela Pisani Elisabetta Giorgini Barbara Rossi Alessandro Damin Francesco Vita Oriano Francescangeli Lorenzo Luciani Rossana Galassi |
| author_facet | Paola Astolfi Michela Pisani Elisabetta Giorgini Barbara Rossi Alessandro Damin Francesco Vita Oriano Francescangeli Lorenzo Luciani Rossana Galassi |
| author_sort | Paola Astolfi |
| collection | DOAJ |
| description | Gold(I) phosphane compounds have recently attracted a renewed interest as potential new protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has been successfully tested against several cancer cell lines and, in particular, against basal-like breast (BLB) cancer, a form characterized by strongly severe diagnosis and short life lapse after classic chemotherapy. Even though the anticancer activity of gold(I) phosphane compounds is thoroughly ascertained, no study has been devoted to the possibility of their delivery in nanovectors. Herein, nonlamellar lyotropic liquid crystalline lipid nanosystems, a promising class of smart materials, have been used to encapsulate gold(I) azolate/phosphane complexes. In particular, ((triphenylphosphine)-gold(I)-(4,5-dichloroimidazolyl-1H-1yl)) (C-I) and ((triphenylphosphine)-gold(I)-(4,5-dicyanoimidazolyl-1H-1yl)) (C-II) have been encapsulated in three different lipid matrices: monoolein (GMO), phytantriol (PHYT) and dioleoyl-phosphatidylethanolamine (DOPE). An integrated experimental approach involving X-ray diffraction and UV resonant Raman (UVRR) spectroscopy, based on synchrotron light and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, has been employed to establish the effects of drug encapsulation on the structure and phase behavior of the host mesophases. The results indicate that gold(I) complexes C-I and C-II are successfully encapsulated in the three lipid matrices as evidenced by the drug-induced phase transitions or by the changes in the mesophase lattice parameters observed in X-ray diffraction experiments and by the spectral changes occurring in UV resonant Raman spectra upon loading the lipid matrices with C-I and C-II. |
| first_indexed | 2024-03-10T16:18:16Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-10T16:18:16Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-0f0cd212631a4c1399f9ee4c4a003acf2023-11-20T13:53:18ZengMDPI AGNanomaterials2079-49912020-09-01109185110.3390/nano10091851Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based DrugsPaola Astolfi0Michela Pisani1Elisabetta Giorgini2Barbara Rossi3Alessandro Damin4Francesco Vita5Oriano Francescangeli6Lorenzo Luciani7Rossana Galassi8Dipartimento SIMAU, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, ItalyDipartimento SIMAU, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, ItalyDipartimento DiSVA, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, ItalyElettra-Sincrotrone Trieste S.C.p.A., S.S. 14-km 163.5, Basovizza, I-34149 Trieste, ItalyDepartment of Chemistry, NIS Centre and INSTM Reference Centre University of Turin, Via G. Quarello 15, I-10135 Turin, ItalyDipartimento SIMAU, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, ItalyDipartimento SIMAU, Università Politecnica delle Marche, Via Brecce Bianche, I-60131 Ancona, ItalyScuola di Scienze e Tecnologie, Divisione Chimica, Università di Camerino, I-62032 Via Sant’Agostino 1, ItalyScuola di Scienze e Tecnologie, Divisione Chimica, Università di Camerino, I-62032 Via Sant’Agostino 1, ItalyGold(I) phosphane compounds have recently attracted a renewed interest as potential new protagonists in cancer therapy. A class of phosphane gold(I) complexes containing azolate ligands has been successfully tested against several cancer cell lines and, in particular, against basal-like breast (BLB) cancer, a form characterized by strongly severe diagnosis and short life lapse after classic chemotherapy. Even though the anticancer activity of gold(I) phosphane compounds is thoroughly ascertained, no study has been devoted to the possibility of their delivery in nanovectors. Herein, nonlamellar lyotropic liquid crystalline lipid nanosystems, a promising class of smart materials, have been used to encapsulate gold(I) azolate/phosphane complexes. In particular, ((triphenylphosphine)-gold(I)-(4,5-dichloroimidazolyl-1H-1yl)) (C-I) and ((triphenylphosphine)-gold(I)-(4,5-dicyanoimidazolyl-1H-1yl)) (C-II) have been encapsulated in three different lipid matrices: monoolein (GMO), phytantriol (PHYT) and dioleoyl-phosphatidylethanolamine (DOPE). An integrated experimental approach involving X-ray diffraction and UV resonant Raman (UVRR) spectroscopy, based on synchrotron light and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, has been employed to establish the effects of drug encapsulation on the structure and phase behavior of the host mesophases. The results indicate that gold(I) complexes C-I and C-II are successfully encapsulated in the three lipid matrices as evidenced by the drug-induced phase transitions or by the changes in the mesophase lattice parameters observed in X-ray diffraction experiments and by the spectral changes occurring in UV resonant Raman spectra upon loading the lipid matrices with C-I and C-II.https://www.mdpi.com/2079-4991/10/9/1851lyotropic cubic and hexagonal mesophasesgold compoundsdrug deliveryphytantriolmonooleinDOPE |
| spellingShingle | Paola Astolfi Michela Pisani Elisabetta Giorgini Barbara Rossi Alessandro Damin Francesco Vita Oriano Francescangeli Lorenzo Luciani Rossana Galassi Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs Nanomaterials lyotropic cubic and hexagonal mesophases gold compounds drug delivery phytantriol monoolein DOPE |
| title | Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs |
| title_full | Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs |
| title_fullStr | Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs |
| title_full_unstemmed | Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs |
| title_short | Synchrotron Characterization of Hexagonal and Cubic Lipidic Phases Loaded with Azolate/Phosphane Gold(I) Compounds: A New Approach to the Uploading of Gold(I)-Based Drugs |
| title_sort | synchrotron characterization of hexagonal and cubic lipidic phases loaded with azolate phosphane gold i compounds a new approach to the uploading of gold i based drugs |
| topic | lyotropic cubic and hexagonal mesophases gold compounds drug delivery phytantriol monoolein DOPE |
| url | https://www.mdpi.com/2079-4991/10/9/1851 |
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