A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

A synthetic BBB-permeable tripeptide GCF confers neuroprotection by increasing glycine in the ischemic brain

Background: We and others have previously demonstrated that glycine is neuroprotective in cerebral ischemia-reperfusion injury. But glycine has low permeability to the blood–brain barrier (BBB). To deliver glycine into the ischemic brain to confer neuroprotection, we designed a novel glycine-contain...

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Bibliographic Details
Main Authors: Juan Chen, Yang Zhuang, Ya Zhang, Huabao Liao, Rui Liu, Jing Cheng, Zhifeng Zhang, Jiangdong Sun, Jingchen Gao, Xiyuran Wang, Shujun Chen, Liang Zhang, Fengyuan Che, Qi Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Pharmacology
Subjects:
ischemic stroke
glycine
BBB
tripeptide
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.950376/full

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