Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion
Background: Induction of medical abortion during the second trimester of pregnancy is considered under certain medical conditions. Abortion in the second trimester of pregnancy could be accompanied by several side effects including hemorrhage and placenta retention. Several types of medications incl...
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2012-09-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-102&slc_lang=en&sid=1 |
| _version_ | 1818482074295730176 |
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| author | Amirabi A Mirzaie M Yekta Z |
| author_facet | Amirabi A Mirzaie M Yekta Z |
| author_sort | Amirabi A |
| collection | DOAJ |
| description | Background: Induction of medical abortion during the second trimester of pregnancy is considered under certain medical conditions. Abortion in the second trimester of pregnancy could be accompanied by several side effects including hemorrhage and placenta retention. Several types of medications including oxytocin, ergots, and prostaglandins are used to control and optimize the third stage of labor and condition of delivery. The aim of this study was to compare the efficacy of intravenous oxytocin versus rectal misoprostol for the management of the third stage of labor during pregnancy termination. Methods: In this randomized clinical trial, 80 pregnant women between 14 to 24 weeks of gestational age were randomly assigned into two intervention groups. Twenty units of intravenous oxytocin was used as the standard regimen and it was compared with 400 µg of rectal misoprostol to manage the third stage of labor.Results: In this study, the frequency of placenta retention was significantly (P=0.034) lower in the misoprostol group (n=3, 7.5%) compared with oxytocin group (n=10, 25%). The average duration of placenta delivery was significantly lower in the misoprostol group (7.95 min Vs. 19.22 min, respectively P=0.015). Decreases in hemoglobin concentration was not significantly different between the two groups. Conclusion: Generally, management of the third stage of labor in second-trimester abortions could reach a better outcome, regarding lower risks of placenta retention and duration of delivery, if rectal misoprostol is administered instead of intravenous oxytocin. |
| first_indexed | 2024-12-10T11:43:21Z |
| format | Article |
| id | doaj.art-0f1113e06f02480cb6d416fcc5403df9 |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-10T11:43:21Z |
| publishDate | 2012-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-0f1113e06f02480cb6d416fcc5403df92022-12-22T01:50:11ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222012-09-01706340350Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortionAmirabi A0Mirzaie M1Yekta Z2 Background: Induction of medical abortion during the second trimester of pregnancy is considered under certain medical conditions. Abortion in the second trimester of pregnancy could be accompanied by several side effects including hemorrhage and placenta retention. Several types of medications including oxytocin, ergots, and prostaglandins are used to control and optimize the third stage of labor and condition of delivery. The aim of this study was to compare the efficacy of intravenous oxytocin versus rectal misoprostol for the management of the third stage of labor during pregnancy termination. Methods: In this randomized clinical trial, 80 pregnant women between 14 to 24 weeks of gestational age were randomly assigned into two intervention groups. Twenty units of intravenous oxytocin was used as the standard regimen and it was compared with 400 µg of rectal misoprostol to manage the third stage of labor.Results: In this study, the frequency of placenta retention was significantly (P=0.034) lower in the misoprostol group (n=3, 7.5%) compared with oxytocin group (n=10, 25%). The average duration of placenta delivery was significantly lower in the misoprostol group (7.95 min Vs. 19.22 min, respectively P=0.015). Decreases in hemoglobin concentration was not significantly different between the two groups. Conclusion: Generally, management of the third stage of labor in second-trimester abortions could reach a better outcome, regarding lower risks of placenta retention and duration of delivery, if rectal misoprostol is administered instead of intravenous oxytocin.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-102&slc_lang=en&sid=1induced medical abortionprostaglandinretained placenta |
| spellingShingle | Amirabi A Mirzaie M Yekta Z Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion Tehran University Medical Journal induced medical abortion prostaglandin retained placenta |
| title | Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion |
| title_full | Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion |
| title_fullStr | Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion |
| title_full_unstemmed | Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion |
| title_short | Comparing intravenous oxytocin Vs. rectal misoprostol for third-stage management after second-trimester medically induced abortion |
| title_sort | comparing intravenous oxytocin vs rectal misoprostol for third stage management after second trimester medically induced abortion |
| topic | induced medical abortion prostaglandin retained placenta |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-102&slc_lang=en&sid=1 |
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