Stereoselective Bioreduction to a Chiral Building Block on a Kilogram Scale

Stereoselective Bioreduction to a Chiral Building Block on a Kilogram Scale

The highly stereoselective bioreduction of ethyl cyclohexanone-2-carboxylate (1) on a kilogram scale is described. Ethyl(1S,2S)-trans-2-hydroxycyclohexane carboxylate (2) was prepared in 56% yield with a diastereomeric ratio (dr) of 99:1 and an enantiomeric ratio (er) of 99.5:0.5 after rec...

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Bibliographic Details
Main Authors: Christelle Jablonski-Lorin, Vito Melillo, Ernst Hungerbühler
Format: Article
Language:deu
Published: Swiss Chemical Society 2003-09-01
Series:CHIMIA
Subjects:
Biotransformation
High stereoselectivity
Scale-up process
S. pombe yeast
Wavebioreactor
Online Access:https://chimia.ch/chimia/article/view/3743

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