Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders
The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/10/2128 |
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| author | Lena Mareczek Carolin Riehl Meike Harms Stephan Reichl |
| author_facet | Lena Mareczek Carolin Riehl Meike Harms Stephan Reichl |
| author_sort | Lena Mareczek |
| collection | DOAJ |
| description | The relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to their manufacturability. D-mannitol is a commonly used excipient in pharmaceutical formulations, especially in oral solid dosage forms, and can be crystallized as three polymorphic forms, of which β is the thermodynamically most stable form and δ is a kinetically stabilized polymorph. A systematic analysis of the powders as starting materials and their respective roller compacted granules is presented to elucidate the multidimensional effects of powder and granules characteristics such as polymorphic form, particle size, and preprocessing on the resulting tablets’ mechanical properties. In direct compression and after roller compaction, δ polymorph displayed superior tableting properties over β mannitol, but was outperformed by spray granulated β mannitol. This could be primarily correlated to the higher specific surface area, leading to higher bonding area and more interparticle bonds within the tablet. Hence, it was shown that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms. |
| first_indexed | 2024-03-09T19:35:14Z |
| format | Article |
| id | doaj.art-0f1253628a284002a4b3708d56b7ae45 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T19:35:14Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-0f1253628a284002a4b3708d56b7ae452023-11-24T01:56:33ZengMDPI AGPharmaceutics1999-49232022-10-011410212810.3390/pharmaceutics14102128Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol PowdersLena Mareczek0Carolin Riehl1Meike Harms2Stephan Reichl3Institute of Pharmaceutical Technology and Biopharmaceutics, Technische Universität Braunschweig, 38106 Braunschweig, GermanyDepartment of Pharmaceutical Technologies, Merck KGaA, 64293 Darmstadt, GermanyDepartment of Pharmaceutical Technologies, Merck KGaA, 64293 Darmstadt, GermanyInstitute of Pharmaceutical Technology and Biopharmaceutics, Technische Universität Braunschweig, 38106 Braunschweig, GermanyThe relevance of the polymorphic form, particle size, and processing of mannitol for the mechanical properties of solid oral dosage forms was examined. Thus, particle and powder properties of spray granulated β D-mannitol, β D-mannitol, and δ D-mannitol were assessed in this study with regards to their manufacturability. D-mannitol is a commonly used excipient in pharmaceutical formulations, especially in oral solid dosage forms, and can be crystallized as three polymorphic forms, of which β is the thermodynamically most stable form and δ is a kinetically stabilized polymorph. A systematic analysis of the powders as starting materials and their respective roller compacted granules is presented to elucidate the multidimensional effects of powder and granules characteristics such as polymorphic form, particle size, and preprocessing on the resulting tablets’ mechanical properties. In direct compression and after roller compaction, δ polymorph displayed superior tableting properties over β mannitol, but was outperformed by spray granulated β mannitol. This could be primarily correlated to the higher specific surface area, leading to higher bonding area and more interparticle bonds within the tablet. Hence, it was shown that surface characteristics and preprocessing can prevail over the impact of polymorphism on manufacturability for oral solid dosage forms.https://www.mdpi.com/1999-4923/14/10/2128mannitolpolymorphismroller compactiondirect compressionpowder characterizationsurface area |
| spellingShingle | Lena Mareczek Carolin Riehl Meike Harms Stephan Reichl Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders Pharmaceutics mannitol polymorphism roller compaction direct compression powder characterization surface area |
| title | Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders |
| title_full | Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders |
| title_fullStr | Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders |
| title_full_unstemmed | Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders |
| title_short | Understanding the Multidimensional Effects of Polymorphism, Particle Size and Processing for D-Mannitol Powders |
| title_sort | understanding the multidimensional effects of polymorphism particle size and processing for d mannitol powders |
| topic | mannitol polymorphism roller compaction direct compression powder characterization surface area |
| url | https://www.mdpi.com/1999-4923/14/10/2128 |
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