The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy
Adaptive radiotherapy (ART) allows control of dosimetric impact of patient anatomical and functional variations over the treatment course, to minimize normal tissue exposure and maximize dose delivery to tumor. We present the first reported case of fan beam computed tomography (FBCT)-guided online A...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | Visualized Cancer Medicine |
| Subjects: | |
| Online Access: | https://vcm.edpsciences.org/articles/vcm/full_html/2023/01/vcm20230003/vcm20230003.html |
| _version_ | 1797333787922661376 |
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| author | Zheng Shuohan Jiang Xiaobo Huang Sijuan Yang Xin Cai Wenpei Li Binghuan He Shumeng Li Hua Chen Ming |
| author_facet | Zheng Shuohan Jiang Xiaobo Huang Sijuan Yang Xin Cai Wenpei Li Binghuan He Shumeng Li Hua Chen Ming |
| author_sort | Zheng Shuohan |
| collection | DOAJ |
| description | Adaptive radiotherapy (ART) allows control of dosimetric impact of patient anatomical and functional variations over the treatment course, to minimize normal tissue exposure and maximize dose delivery to tumor. We present the first reported case of fan beam computed tomography (FBCT)-guided online ART for the treatment of small cell lung cancer (SCLC). A 62-year-old woman was diagnosed with histologically proven limited-stage SCLC. During definitive radiochemotherapy (50 Gy in daily fractions of 2.5 Gy), the tumor shrinkage resulted in an unexpected dose escalation to organs at risk (OAR). To correct the dose change, she received an online ART treatment session in our center with four-dimensional FBCT before the 12th fraction was delivered. The application of online ART, including imaging, recontouring and replanning, was feasible as the total treatment time was <25 min. Further research is warranted to verify the benefit of online ART in individualized treatment. |
| first_indexed | 2024-03-08T08:10:11Z |
| format | Article |
| id | doaj.art-0f131f65ae404c5ca624b13b5b694e1d |
| institution | Directory Open Access Journal |
| issn | 2740-4218 |
| language | English |
| last_indexed | 2024-03-08T08:10:11Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Visualized Cancer Medicine |
| spelling | doaj.art-0f131f65ae404c5ca624b13b5b694e1d2024-02-02T08:43:20ZengEDP SciencesVisualized Cancer Medicine2740-42182023-01-014710.1051/vcm/2023003vcm20230003The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapyZheng Shuohan0Jiang Xiaobo1Huang Sijuan2Yang Xin3Cai Wenpei4Li Binghuan5He Shumeng6Li Hua7Chen Ming8Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterShenzhen United Imaging Research Institute of Innovative Medical EquipmentShanghai United Imaging Healthcare Co., LtdUnited Imaging Research Institute of Intelligent ImagingShenzhen United Imaging Research Institute of Innovative Medical EquipmentDepartment of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterAdaptive radiotherapy (ART) allows control of dosimetric impact of patient anatomical and functional variations over the treatment course, to minimize normal tissue exposure and maximize dose delivery to tumor. We present the first reported case of fan beam computed tomography (FBCT)-guided online ART for the treatment of small cell lung cancer (SCLC). A 62-year-old woman was diagnosed with histologically proven limited-stage SCLC. During definitive radiochemotherapy (50 Gy in daily fractions of 2.5 Gy), the tumor shrinkage resulted in an unexpected dose escalation to organs at risk (OAR). To correct the dose change, she received an online ART treatment session in our center with four-dimensional FBCT before the 12th fraction was delivered. The application of online ART, including imaging, recontouring and replanning, was feasible as the total treatment time was <25 min. Further research is warranted to verify the benefit of online ART in individualized treatment.https://vcm.edpsciences.org/articles/vcm/full_html/2023/01/vcm20230003/vcm20230003.htmlonline adaptive radiotherapysmall cell lung cancerfan beam computed tomographyorgans at risk |
| spellingShingle | Zheng Shuohan Jiang Xiaobo Huang Sijuan Yang Xin Cai Wenpei Li Binghuan He Shumeng Li Hua Chen Ming The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy Visualized Cancer Medicine online adaptive radiotherapy small cell lung cancer fan beam computed tomography organs at risk |
| title | The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy |
| title_full | The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy |
| title_fullStr | The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy |
| title_full_unstemmed | The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy |
| title_short | The first reported case of a patient with small cell lung cancer treated with fan beam computed tomography-guided online adaptive radiotherapy |
| title_sort | first reported case of a patient with small cell lung cancer treated with fan beam computed tomography guided online adaptive radiotherapy |
| topic | online adaptive radiotherapy small cell lung cancer fan beam computed tomography organs at risk |
| url | https://vcm.edpsciences.org/articles/vcm/full_html/2023/01/vcm20230003/vcm20230003.html |
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