Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study
Abstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, cl...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-11-01
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| Series: | European Journal of Hybrid Imaging |
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| Online Access: | https://doi.org/10.1186/s41824-021-00112-3 |
| _version_ | 1818683604592492544 |
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| author | Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana |
| author_facet | Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana |
| author_sort | Ana Carolina Trevisan |
| collection | DOAJ |
| description | Abstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores. |
| first_indexed | 2024-12-17T10:37:23Z |
| format | Article |
| id | doaj.art-0f14c9cc19a24a5482b36e600d395802 |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-12-17T10:37:23Z |
| publishDate | 2021-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-0f14c9cc19a24a5482b36e600d3958022022-12-21T21:52:20ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362021-11-015111310.1186/s41824-021-00112-3Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect studyAna Carolina Trevisan0Leonardo Alexandre-Santos1Rodrigo Luppino Assad2Emerson Nobuyuki Itikawa3Felipe Arriva Pitella4Mery Kato5José Henrique Silvah6Antonio Carlos Santos7Paulo Louzada-Junior8Lauro Wichert-Ana9Nuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloNuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloDivision of Rheumatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São PauloPhysics Institute, Federal University of GoiásNuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloNuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloNuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloMagnetic Resonance Laboratory, Department of Medical Imaging, Hematology, and Clinical Oncology Ribeirão Preto Medical School, University of São PauloDivision of Rheumatology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São PauloNuclear Medicine and PET/CT Laboratory. Ribeirão Preto Medical School, Post Graduate Program in Internal Medicine, University of São PauloAbstract This study was addressed to evaluate the temporal and spatial changes in regional cerebral blood flow (rCBF) of patients with neuropsychiatric systemic lupus erythematosus (NPSLE). Our objective was to correlate the subtracted SPECT coregistered to MRI features (SISCOM) with demographic, clinical and laboratory findings to shed light upon the pathophysiological evolution of the NPSLE. Twenty-six NPSLE patients with MRI and pre- and post-treatment brain SPECT with [99mTc]Tc-ECD. SISCOM features were categorized as improvement, worsening, activation and/or deactivation of rCBF findings. Patients mean age of 43.19 years and 65.38% white were evaluated. The patients mean age at onset of SLE was 26.05 and 42.29 for NPSLE. The mean time between the onset of SLE and first NPSLE symptoms was 05.57 years. The disease has already been initiated as NPSLE in 4 patients. The SLEDAI average score was 31.69 and the SLICC/ACR-DI score was 06.96. The patients underwent an average of 09.23 cyclophosphamide. The SISCOM findings showed functional and pathological states on different brain regions. The rCBF changes were not associated with index scores. There was, however, a trend towards an association between lower SLEDAI scores with improvement and higher SLEDAI with worsening in SISCOM, Also a trend of association between lower SLICC score with improvement, and higher SLICC with worsening. The female gender was predictive of activation and worsening, separately, and deactivation and worsening in a set. Non-white patients were predictive of worsening. The seizure was predictive of deactivation separately, and deactivation and worsening in a set. Finally, normal C3 was a predictor of improvement. The present study showed dynamic brain changes in NPSLE patients. SISCOM technique showed improved rCBF in some brain areas, and worsening, activation and deactivation in others. There were associations between rCBF changes and gender, skin colour and complement C3 and association trends with SLEDAI and SLICC scores.https://doi.org/10.1186/s41824-021-00112-3Systemic lupus erythematosusNeuropsychiatric formBrain SPECTSISCOM |
| spellingShingle | Ana Carolina Trevisan Leonardo Alexandre-Santos Rodrigo Luppino Assad Emerson Nobuyuki Itikawa Felipe Arriva Pitella Mery Kato José Henrique Silvah Antonio Carlos Santos Paulo Louzada-Junior Lauro Wichert-Ana Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study European Journal of Hybrid Imaging Systemic lupus erythematosus Neuropsychiatric form Brain SPECT SISCOM |
| title | Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study |
| title_full | Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study |
| title_fullStr | Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study |
| title_full_unstemmed | Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study |
| title_short | Temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus: a subtraction brain spect study |
| title_sort | temporal and spatial changes in cerebral blood flow in neuropsychiatric systemic lupus erythematosus a subtraction brain spect study |
| topic | Systemic lupus erythematosus Neuropsychiatric form Brain SPECT SISCOM |
| url | https://doi.org/10.1186/s41824-021-00112-3 |
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