Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis
Abstract Background Concerning ascending trend in the prevalence of chronic type II diabetes, prevention and the development of an effective approach after the recognition of at-risk individuals is crucial. This study aims to investigate comparing the influence of lifestyle modification and metformi...
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-023-01445-9 |
| _version_ | 1797559066660175872 |
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| author | Sayedah Sarah Mousavi Seyedeh Mahdieh Namayandeh Hossein Fallahzadeh Masoud Rahmanian Mehdi Mollahosseini |
| author_facet | Sayedah Sarah Mousavi Seyedeh Mahdieh Namayandeh Hossein Fallahzadeh Masoud Rahmanian Mehdi Mollahosseini |
| author_sort | Sayedah Sarah Mousavi |
| collection | DOAJ |
| description | Abstract Background Concerning ascending trend in the prevalence of chronic type II diabetes, prevention and the development of an effective approach after the recognition of at-risk individuals is crucial. This study aims to investigate comparing the influence of lifestyle modification and metformin interventions in the prevention of type II diabetes developments. Method The search was conducted using PubMed, Google Scholar, Scopus and Web of Science databases. The inclusion criteria include randomized controlled trials (RCT) which studied both lifestyle modification and metformin interventions in the population above 18 years old without a history of any type of diabetes. After excluding studies with intervention time of fewer than 6 months, a systematic review and meta-analysis were performed to evaluate relative risk (RR) with a confidence interval (CI) of 95% of type II diabetes development. Results Data from 5 studies were included in the meta-analysis. The population also consists of individuals with a mean age of 50 years old with BMI and FBS of 35.5 and 104.7 mg/dl respectively. Participants range of prevention years was between 2–3 years with a mean of 2.8 years. Lifestyle modification decreases the probability of the incidence of type II diabetes by 25.3% (RR: 0.747, 95% CI, 0.6—0.92) compared to the metformin intervention (p-value = 0.007). Our results indicate that long-term lifestyle modifications can prevent diabetes type II and decrease diabetes mellitus incidence down to one-quarter in comparison to metformin. Conclusion Lifestyle modification can be more efficacious than metformin in diminishing the incidence of type II diabetes. Therefore, lifestyle modification can be a therapeutic strategy for controlling type II diabetes incidence, especially in high-risk individuals. |
| first_indexed | 2024-03-10T17:40:27Z |
| format | Article |
| id | doaj.art-0f16aee73ef04960808d1525bec3902d |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-03-10T17:40:27Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-0f16aee73ef04960808d1525bec3902d2023-11-20T09:42:10ZengBMCBMC Endocrine Disorders1472-68232023-09-0123111110.1186/s12902-023-01445-9Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysisSayedah Sarah Mousavi0Seyedeh Mahdieh Namayandeh1Hossein Fallahzadeh2Masoud Rahmanian3Mehdi Mollahosseini4Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health ServicesCenter for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health ServicesCenter for Healthcare Data Modeling, Departments of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health ServicesYazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences and Health ServicesDepartment of Community Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences and Health ServicesAbstract Background Concerning ascending trend in the prevalence of chronic type II diabetes, prevention and the development of an effective approach after the recognition of at-risk individuals is crucial. This study aims to investigate comparing the influence of lifestyle modification and metformin interventions in the prevention of type II diabetes developments. Method The search was conducted using PubMed, Google Scholar, Scopus and Web of Science databases. The inclusion criteria include randomized controlled trials (RCT) which studied both lifestyle modification and metformin interventions in the population above 18 years old without a history of any type of diabetes. After excluding studies with intervention time of fewer than 6 months, a systematic review and meta-analysis were performed to evaluate relative risk (RR) with a confidence interval (CI) of 95% of type II diabetes development. Results Data from 5 studies were included in the meta-analysis. The population also consists of individuals with a mean age of 50 years old with BMI and FBS of 35.5 and 104.7 mg/dl respectively. Participants range of prevention years was between 2–3 years with a mean of 2.8 years. Lifestyle modification decreases the probability of the incidence of type II diabetes by 25.3% (RR: 0.747, 95% CI, 0.6—0.92) compared to the metformin intervention (p-value = 0.007). Our results indicate that long-term lifestyle modifications can prevent diabetes type II and decrease diabetes mellitus incidence down to one-quarter in comparison to metformin. Conclusion Lifestyle modification can be more efficacious than metformin in diminishing the incidence of type II diabetes. Therefore, lifestyle modification can be a therapeutic strategy for controlling type II diabetes incidence, especially in high-risk individuals.https://doi.org/10.1186/s12902-023-01445-9DiabetesLifestyle modificationMetforminPrimary preventionSystematic reviewMeta-analysis |
| spellingShingle | Sayedah Sarah Mousavi Seyedeh Mahdieh Namayandeh Hossein Fallahzadeh Masoud Rahmanian Mehdi Mollahosseini Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis BMC Endocrine Disorders Diabetes Lifestyle modification Metformin Primary prevention Systematic review Meta-analysis |
| title | Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis |
| title_full | Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis |
| title_fullStr | Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis |
| title_full_unstemmed | Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis |
| title_short | Comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type II diabetes: a systematic review and meta-analysis |
| title_sort | comparing the effectiveness of metformin with lifestyle modification for the primary prevention of type ii diabetes a systematic review and meta analysis |
| topic | Diabetes Lifestyle modification Metformin Primary prevention Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12902-023-01445-9 |
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