Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets
This study aimed to investigate the beneficial effect of baicalin–zinc complex (BZN) on intestinal microorganisms in deoxynivalenol (DON)-challenged piglets and the association between intestinal microorganisms and host immunity and hormone secretion. Forty weaned piglets were randomly divided into...
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| Format: | Article |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.738281/full |
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| author | Andong Zha Andong Zha Ruiqi Tu Zhijuan Cui Ming Qi Ming Qi Simeng Liao Simeng Liao Jing Wang Bie Tan Peng Liao |
| author_facet | Andong Zha Andong Zha Ruiqi Tu Zhijuan Cui Ming Qi Ming Qi Simeng Liao Simeng Liao Jing Wang Bie Tan Peng Liao |
| author_sort | Andong Zha |
| collection | DOAJ |
| description | This study aimed to investigate the beneficial effect of baicalin–zinc complex (BZN) on intestinal microorganisms in deoxynivalenol (DON)-challenged piglets and the association between intestinal microorganisms and host immunity and hormone secretion. Forty weaned piglets were randomly divided into four treatments with 10 piglets in each treatment: (1) control (Con) group (pigs fed basal diet); (2) DON group (pigs fed 4 mg DON/kg basal diet); (3) BZN group (pigs fed 0.5% BZN basal diet); and (4) DBZN group (pigs fed 4 mg DON/kg and 0.5% BZN basal diet). The experiment lasted for 14 days. The BZN supplementation in DON-contaminated diets changed the intestinal microbiota composition and increased intestinal microbial richness and diversity of piglets. The BZN supplementation in DON-contaminated diets also alleviated the inflammatory responses of piglets and modulated the secretion of hormones related to the growth axis. Moreover, microbiota composition was associated with inflammatory and hormone secretion. In conclusion, BZN alleviated inflammatory response and hormone secretion in piglets, which is associated with the intestinal microbiome. |
| first_indexed | 2024-12-13T20:21:04Z |
| format | Article |
| id | doaj.art-0f172e1186bb40afbe68332a529466b7 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-13T20:21:04Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-0f172e1186bb40afbe68332a529466b72022-12-21T23:32:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-10-01810.3389/fnut.2021.738281738281Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced PigletsAndong Zha0Andong Zha1Ruiqi Tu2Zhijuan Cui3Ming Qi4Ming Qi5Simeng Liao6Simeng Liao7Jing Wang8Bie Tan9Peng Liao10Chinese Academy of Sciences, Institute of Subtropical Agriculture, Changsha, ChinaCollege of Resource and Environment, University of Chinese Academy of Sciences, Beijing, ChinaCollege of Veterinary Medicine, Northwest A & F University, Yangling, ChinaDepartment of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaChinese Academy of Sciences, Institute of Subtropical Agriculture, Changsha, ChinaCollege of Resource and Environment, University of Chinese Academy of Sciences, Beijing, ChinaChinese Academy of Sciences, Institute of Subtropical Agriculture, Changsha, ChinaCollege of Resource and Environment, University of Chinese Academy of Sciences, Beijing, ChinaDepartment of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaDepartment of Animal Science and Technology, Hunan Agricultural University, Changsha, ChinaChinese Academy of Sciences, Institute of Subtropical Agriculture, Changsha, ChinaThis study aimed to investigate the beneficial effect of baicalin–zinc complex (BZN) on intestinal microorganisms in deoxynivalenol (DON)-challenged piglets and the association between intestinal microorganisms and host immunity and hormone secretion. Forty weaned piglets were randomly divided into four treatments with 10 piglets in each treatment: (1) control (Con) group (pigs fed basal diet); (2) DON group (pigs fed 4 mg DON/kg basal diet); (3) BZN group (pigs fed 0.5% BZN basal diet); and (4) DBZN group (pigs fed 4 mg DON/kg and 0.5% BZN basal diet). The experiment lasted for 14 days. The BZN supplementation in DON-contaminated diets changed the intestinal microbiota composition and increased intestinal microbial richness and diversity of piglets. The BZN supplementation in DON-contaminated diets also alleviated the inflammatory responses of piglets and modulated the secretion of hormones related to the growth axis. Moreover, microbiota composition was associated with inflammatory and hormone secretion. In conclusion, BZN alleviated inflammatory response and hormone secretion in piglets, which is associated with the intestinal microbiome.https://www.frontiersin.org/articles/10.3389/fnut.2021.738281/fullbaicalin-zinc complexdeoxynivalenolintestinal microbiomehormone secretioninflammatory responsesweaned piglets |
| spellingShingle | Andong Zha Andong Zha Ruiqi Tu Zhijuan Cui Ming Qi Ming Qi Simeng Liao Simeng Liao Jing Wang Bie Tan Peng Liao Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets Frontiers in Nutrition baicalin-zinc complex deoxynivalenol intestinal microbiome hormone secretion inflammatory responses weaned piglets |
| title | Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets |
| title_full | Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets |
| title_fullStr | Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets |
| title_full_unstemmed | Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets |
| title_short | Baicalin–Zinc Complex Alleviates Inflammatory Responses and Hormone Profiles by Microbiome in Deoxynivalenol Induced Piglets |
| title_sort | baicalin zinc complex alleviates inflammatory responses and hormone profiles by microbiome in deoxynivalenol induced piglets |
| topic | baicalin-zinc complex deoxynivalenol intestinal microbiome hormone secretion inflammatory responses weaned piglets |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.738281/full |
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