Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series
Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case ser...
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| Format: | Article |
| Language: | English |
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Mattioli1885
2017-01-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2751 |
| _version_ | 1819003475338461184 |
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| author | Shahrzad Zonoozi |
| author_facet | Shahrzad Zonoozi |
| author_sort | Shahrzad Zonoozi |
| collection | DOAJ |
| description | Sitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM).
This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with β-TM and DM.
Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects.
This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist. |
| first_indexed | 2024-12-20T23:21:35Z |
| format | Article |
| id | doaj.art-0f1922ae385c46fd8a7005278f0657b3 |
| institution | Directory Open Access Journal |
| issn | 2035-3006 |
| language | English |
| last_indexed | 2024-12-20T23:21:35Z |
| publishDate | 2017-01-01 |
| publisher | Mattioli1885 |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj.art-0f1922ae385c46fd8a7005278f0657b32022-12-21T19:23:30ZengMattioli1885Mediterranean Journal of Hematology and Infectious Diseases2035-30062017-01-0191e2017004e201700410.4084/mjhid.2017.0041658Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case SeriesShahrzad ZonooziSitagliptin, a modern antidiabetic agent which is weight neutral and associated with low rate of hypoglycaemias, is being increasingly used in type 2 diabetes mellitus (DM). However there is paucity of data about its efficacy and safety in beta-thalassaemia major (β-TM). This retrospective case series of five patients (mean age of 45 years) is the first study evaluating the use of sitagliptin in patients with β-TM and DM. Four patients responded well to sitagliptin, as evidenced by decrease in fructosamine by 77 and 96µmol/L (equivalent reduction in HbA1c of 1.5% and 1.9%) observed in two patients and reduction in the frequency of hypoglycaemia without worsening glycaemic control in two others. One patient did not respond to sitagliptin. No patients reported significant side effects. This study provides evidence that sitagliptin may be considered, with caution, for use in patients with β-TM and DM, under the close monitoring of a Diabetologist.http://www.mjhid.org/index.php/mjhid/article/view/2751Thalassemic Syndromes, Diabetes |
| spellingShingle | Shahrzad Zonoozi Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series Mediterranean Journal of Hematology and Infectious Diseases Thalassemic Syndromes, Diabetes |
| title | Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series |
| title_full | Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series |
| title_fullStr | Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series |
| title_full_unstemmed | Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series |
| title_short | Effectiveness and Safety of Sitagliptin in Patients with Beta-thalassaemia Major and Diabetes Mellitus: A Case Series |
| title_sort | effectiveness and safety of sitagliptin in patients with beta thalassaemia major and diabetes mellitus a case series |
| topic | Thalassemic Syndromes, Diabetes |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2751 |
| work_keys_str_mv | AT shahrzadzonoozi effectivenessandsafetyofsitagliptininpatientswithbetathalassaemiamajoranddiabetesmellitusacaseseries |