phasebook: haplotype-aware de novo assembly of diploid genomes from long reads

phasebook: haplotype-aware de novo assembly of diploid genomes from long reads

Abstract Haplotype-aware diploid genome assembly is crucial in genomics, precision medicine, and many other disciplines. Long-read sequencing technologies have greatly improved genome assembly. However, current long-read assemblers are either reference based, so introduce biases, or fail to capture...

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Bibliographic Details
Main Authors: Xiao Luo, Xiongbin Kang, Alexander Schönhuth
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Genome Biology
Subjects:
Genome assembly
Haplotype
Diploid
Long reads
Online Access:https://doi.org/10.1186/s13059-021-02512-x

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