Amoebic Foraging Model of Metastatic Cancer Cells

The Lévy walk is a pattern that is often seen in the movement of living organisms; it has both ballistic and random features and is a behavior that has been recognized in various animals and unicellular organisms, such as amoebae, in recent years. We proposed an amoeba locomotion model that implemen...

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Bibliographic Details
Main Authors: Daiki Andoh, Yukio-Pegio Gunji
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Symmetry
Subjects:
Online Access:https://www.mdpi.com/2073-8994/13/7/1140
Description
Summary:The Lévy walk is a pattern that is often seen in the movement of living organisms; it has both ballistic and random features and is a behavior that has been recognized in various animals and unicellular organisms, such as amoebae, in recent years. We proposed an amoeba locomotion model that implements Bayesian and inverse Bayesian inference as a Lévy walk algorithm that balances exploration and exploitation, and through a comparison with general random walks, we confirmed its effectiveness. While Bayesian inference is expressed only by <i>P</i>(<i>h</i>) = <i>P</i>(<i>h</i>|<i>d</i>), we introduce inverse Bayesian inference expressed as <i>P</i>(<i>d</i>|<i>h</i>) = <i>P</i>(<i>d</i>) in a symmetry fashion. That symmetry contributes to balancing contracting and expanding the probability space. Additionally, the conditions of various environments were set, and experimental results were obtained that corresponded to changes in gait patterns with respect to changes in the conditions of actual metastatic cancer cells.
ISSN:2073-8994