Development of a comprehensive noninvasive prenatal test

Development of a comprehensive noninvasive prenatal test

Abstract Our aim was to develop and apply a comprehensive noninvasive prenatal test (NIPT) by using high-coverage targeted next-generation sequencing to estimate fetal fraction, determine fetal sex, and detect trisomy and monogenic disease without parental genotype information. We analyzed 45 pregna...

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Bibliographic Details
Main Authors:	Carolina Malcher, Guilherme L. Yamamoto, Philip Burnham, Suzana A.M. Ezquina, Naila C.V. Lourenço, Sahilla Balkassmi, David S. Marco Antonio, Gabriella S.P. Hsia, Thomaz Gollop, Rita C. Pavanello, Marco Antonio Lopes, Egbert Bakker, Mayana Zatz, Débora Bertola, Iwijn De Vlaminck, Maria Rita Passos-Bueno
Format:	Article
Language:	English
Published:	Sociedade Brasileira de Genética 2018-07-01
Series:	Genetics and Molecular Biology
Subjects:	Cell-free DNA next-generation sequencing trisomy noninvasive prenatal test fetal fraction
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400545&lng=en&tlng=en

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