Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications
Central nervous system (CNS) disease is a general term for a series of complex and diverse diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, and amyotrophic lateral sclerosis (ALS). Interneuron and neuron-glia cells communi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1004221/full |
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| author | Zhong-Yu Wang Zeng-Jin Wen Hai-Ming Xu Hai-Ming Xu Yu Zhang Yin-Feng Zhang |
| author_facet | Zhong-Yu Wang Zeng-Jin Wen Hai-Ming Xu Hai-Ming Xu Yu Zhang Yin-Feng Zhang |
| author_sort | Zhong-Yu Wang |
| collection | DOAJ |
| description | Central nervous system (CNS) disease is a general term for a series of complex and diverse diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, and amyotrophic lateral sclerosis (ALS). Interneuron and neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron and neuron-glia cells by transferring their contents, such as proteins, lipids, and ncRNAs, constituting a novel form of cell-to-cell interaction and communication. Exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs), regulate physiological functions and maintain CNS homeostasis. Exosomes are regarded as extracellular messengers that transfer ncRNAs between neurons and body fluids due to their ability to cross the blood-brain barrier. This review aims to summarize the current understanding of exosomal ncRNAs in CNS diseases, including prospective diagnostic biomarkers, pathological regulators, therapeutic strategies and clinical applications. We also provide an all-sided discussion of the comparison with some similar CNS diseases and the main limitations and challenges for exosomal ncRNAs in clinical applications. |
| first_indexed | 2024-04-13T21:12:54Z |
| format | Article |
| id | doaj.art-0f1c877ae32d486fbf1a6b58c75d2c61 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T21:12:54Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-0f1c877ae32d486fbf1a6b58c75d2c612022-12-22T02:29:46ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-11-011510.3389/fnmol.2022.10042211004221Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applicationsZhong-Yu Wang0Zeng-Jin Wen1Hai-Ming Xu2Hai-Ming Xu3Yu Zhang4Yin-Feng Zhang5Institute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaDepartment of Occupational and Environmental Medicine, School of Public Health and Management, Ningxia Medical University, Yinchuan, ChinaThe Key Laboratory of Environmental Factors and Chronic Disease Control of Ningxia, Ningxia Medical University, Yinchuan, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaInstitute for Translational Medicine, The Affiliated Hospital of Qingdao University, College of Medicine, Qingdao University, Qingdao, ChinaCentral nervous system (CNS) disease is a general term for a series of complex and diverse diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), CNS tumors, stroke, epilepsy, and amyotrophic lateral sclerosis (ALS). Interneuron and neuron-glia cells communicate with each other through their homeostatic microenvironment. Exosomes in the microenvironment have crucial impacts on interneuron and neuron-glia cells by transferring their contents, such as proteins, lipids, and ncRNAs, constituting a novel form of cell-to-cell interaction and communication. Exosomal noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and PIWI-interacting RNAs (piRNAs), regulate physiological functions and maintain CNS homeostasis. Exosomes are regarded as extracellular messengers that transfer ncRNAs between neurons and body fluids due to their ability to cross the blood-brain barrier. This review aims to summarize the current understanding of exosomal ncRNAs in CNS diseases, including prospective diagnostic biomarkers, pathological regulators, therapeutic strategies and clinical applications. We also provide an all-sided discussion of the comparison with some similar CNS diseases and the main limitations and challenges for exosomal ncRNAs in clinical applications.https://www.frontiersin.org/articles/10.3389/fnmol.2022.1004221/fullexosomenoncoding RNAcentral nervous systembiomarkerspathophysiologytherapy |
| spellingShingle | Zhong-Yu Wang Zeng-Jin Wen Hai-Ming Xu Hai-Ming Xu Yu Zhang Yin-Feng Zhang Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications Frontiers in Molecular Neuroscience exosome noncoding RNA central nervous system biomarkers pathophysiology therapy |
| title | Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications |
| title_full | Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications |
| title_fullStr | Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications |
| title_full_unstemmed | Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications |
| title_short | Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications |
| title_sort | exosomal noncoding rnas in central nervous system diseases biological functions and potential clinical applications |
| topic | exosome noncoding RNA central nervous system biomarkers pathophysiology therapy |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1004221/full |
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