Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
Bibliographic Details
| Main Authors: |
Eduardo Gomez-Bañuelos,
Yikai Yu,
Jessica Li,
Kevin S. Cashman,
Merlin Paz,
Maria Isabel Trejo-Zambrano,
Regina Bugrovsky,
Youliang Wang,
Asiya Seema Chida,
Cheryl A. Sherman-Baust,
Dylan P. Ferris,
Daniel W. Goldman,
Erika Darrah,
Michelle Petri,
Iñaki Sanz,
Felipe Andrade |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-023-37083-x
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