Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus

Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.

Bibliographic Details
Main Authors: Eduardo Gomez-Bañuelos, Yikai Yu, Jessica Li, Kevin S. Cashman, Merlin Paz, Maria Isabel Trejo-Zambrano, Regina Bugrovsky, Youliang Wang, Asiya Seema Chida, Cheryl A. Sherman-Baust, Dylan P. Ferris, Daniel W. Goldman, Erika Darrah, Michelle Petri, Iñaki Sanz, Felipe Andrade
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37083-x
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author Eduardo Gomez-Bañuelos
Yikai Yu
Jessica Li
Kevin S. Cashman
Merlin Paz
Maria Isabel Trejo-Zambrano
Regina Bugrovsky
Youliang Wang
Asiya Seema Chida
Cheryl A. Sherman-Baust
Dylan P. Ferris
Daniel W. Goldman
Erika Darrah
Michelle Petri
Iñaki Sanz
Felipe Andrade
author_facet Eduardo Gomez-Bañuelos
Yikai Yu
Jessica Li
Kevin S. Cashman
Merlin Paz
Maria Isabel Trejo-Zambrano
Regina Bugrovsky
Youliang Wang
Asiya Seema Chida
Cheryl A. Sherman-Baust
Dylan P. Ferris
Daniel W. Goldman
Erika Darrah
Michelle Petri
Iñaki Sanz
Felipe Andrade
author_sort Eduardo Gomez-Bañuelos
collection DOAJ
description Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
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spelling doaj.art-0f1da98ab1e94d54a8c743920c6857c62023-03-22T11:47:03ZengNature PortfolioNature Communications2041-17232023-03-0114111410.1038/s41467-023-37083-xAffinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosusEduardo Gomez-Bañuelos0Yikai Yu1Jessica Li2Kevin S. Cashman3Merlin Paz4Maria Isabel Trejo-Zambrano5Regina Bugrovsky6Youliang Wang7Asiya Seema Chida8Cheryl A. Sherman-Baust9Dylan P. Ferris10Daniel W. Goldman11Erika Darrah12Michelle Petri13Iñaki Sanz14Felipe Andrade15Division of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityGene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on AgingDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDivision of Rheumatology, The Johns Hopkins University School of MedicineAntibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.https://doi.org/10.1038/s41467-023-37083-x
spellingShingle Eduardo Gomez-Bañuelos
Yikai Yu
Jessica Li
Kevin S. Cashman
Merlin Paz
Maria Isabel Trejo-Zambrano
Regina Bugrovsky
Youliang Wang
Asiya Seema Chida
Cheryl A. Sherman-Baust
Dylan P. Ferris
Daniel W. Goldman
Erika Darrah
Michelle Petri
Iñaki Sanz
Felipe Andrade
Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
Nature Communications
title Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
title_full Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
title_fullStr Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
title_full_unstemmed Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
title_short Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
title_sort affinity maturation generates pathogenic antibodies with dual reactivity to dnase1l3 and dsdna in systemic lupus erythematosus
url https://doi.org/10.1038/s41467-023-37083-x
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