Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus
Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2023-03-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-37083-x |
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author | Eduardo Gomez-Bañuelos Yikai Yu Jessica Li Kevin S. Cashman Merlin Paz Maria Isabel Trejo-Zambrano Regina Bugrovsky Youliang Wang Asiya Seema Chida Cheryl A. Sherman-Baust Dylan P. Ferris Daniel W. Goldman Erika Darrah Michelle Petri Iñaki Sanz Felipe Andrade |
author_facet | Eduardo Gomez-Bañuelos Yikai Yu Jessica Li Kevin S. Cashman Merlin Paz Maria Isabel Trejo-Zambrano Regina Bugrovsky Youliang Wang Asiya Seema Chida Cheryl A. Sherman-Baust Dylan P. Ferris Daniel W. Goldman Erika Darrah Michelle Petri Iñaki Sanz Felipe Andrade |
author_sort | Eduardo Gomez-Bañuelos |
collection | DOAJ |
description | Antibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA. |
first_indexed | 2024-04-09T22:46:36Z |
format | Article |
id | doaj.art-0f1da98ab1e94d54a8c743920c6857c6 |
institution | Directory Open Access Journal |
issn | 2041-1723 |
language | English |
last_indexed | 2024-04-09T22:46:36Z |
publishDate | 2023-03-01 |
publisher | Nature Portfolio |
record_format | Article |
series | Nature Communications |
spelling | doaj.art-0f1da98ab1e94d54a8c743920c6857c62023-03-22T11:47:03ZengNature PortfolioNature Communications2041-17232023-03-0114111410.1038/s41467-023-37083-xAffinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosusEduardo Gomez-Bañuelos0Yikai Yu1Jessica Li2Kevin S. Cashman3Merlin Paz4Maria Isabel Trejo-Zambrano5Regina Bugrovsky6Youliang Wang7Asiya Seema Chida8Cheryl A. Sherman-Baust9Dylan P. Ferris10Daniel W. Goldman11Erika Darrah12Michelle Petri13Iñaki Sanz14Felipe Andrade15Division of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Rheumatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityGene Regulation Section, Laboratory of Molecular Biology and Immunology, National Institute on AgingDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDivision of Rheumatology, The Johns Hopkins University School of MedicineDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory UniversityDivision of Rheumatology, The Johns Hopkins University School of MedicineAntibodies directed against DNA in systemic lupus erythematosus are functionally diverse. This study demonstrates that DNAse1L3 is the primary target of a subset of autoantibodies previously considered specific for double-stranded DNA.https://doi.org/10.1038/s41467-023-37083-x |
spellingShingle | Eduardo Gomez-Bañuelos Yikai Yu Jessica Li Kevin S. Cashman Merlin Paz Maria Isabel Trejo-Zambrano Regina Bugrovsky Youliang Wang Asiya Seema Chida Cheryl A. Sherman-Baust Dylan P. Ferris Daniel W. Goldman Erika Darrah Michelle Petri Iñaki Sanz Felipe Andrade Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus Nature Communications |
title | Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus |
title_full | Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus |
title_fullStr | Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus |
title_full_unstemmed | Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus |
title_short | Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus |
title_sort | affinity maturation generates pathogenic antibodies with dual reactivity to dnase1l3 and dsdna in systemic lupus erythematosus |
url | https://doi.org/10.1038/s41467-023-37083-x |
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