Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling
Summary: Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into f...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-09-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124720311542 |
| _version_ | 1811213810012258304 |
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| author | Grzegorz Chwastek Michal A. Surma Sandra Rizk Daniel Grosser Oksana Lavrynenko Magdalena Rucińska Helena Jambor James Sáenz |
| author_facet | Grzegorz Chwastek Michal A. Surma Sandra Rizk Daniel Grosser Oksana Lavrynenko Magdalena Rucińska Helena Jambor James Sáenz |
| author_sort | Grzegorz Chwastek |
| collection | DOAJ |
| description | Summary: Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of membrane adaptation. Using shotgun lipidomics, we examine the simple yet, as we show here, adaptive lipidome of the plant-associated Gram-negative bacterium Methylobacterium extorquens. We observe that minimally 11 lipids account for 90% of total variability, thus constraining the upper limit of variable lipids required for an adaptive living membrane. Through lipid features analysis, we reveal that acyl chain remodeling is not evenly distributed across lipid classes, resulting in headgroup-specific effects of acyl chain variability on membrane properties. Results herein implicate headgroup-specific acyl chain remodeling as a mechanism for fine-tuning the membrane’s physical state and provide a resource for using M. extorquens to explore the design principles of living membranes. |
| first_indexed | 2024-04-12T05:52:27Z |
| format | Article |
| id | doaj.art-0f1ec137fa0a47098fba5ec8ffddb057 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-12T05:52:27Z |
| publishDate | 2020-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-0f1ec137fa0a47098fba5ec8ffddb0572022-12-22T03:45:16ZengElsevierCell Reports2211-12472020-09-013212108165Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome RemodelingGrzegorz Chwastek0Michal A. Surma1Sandra Rizk2Daniel Grosser3Oksana Lavrynenko4Magdalena Rucińska5Helena Jambor6James Sáenz7Technische Universität Dresden, B CUBE, Tatzberg 41, Dresden, GermanyLipotype GmbH, Tatzberg 47, Dresden, GermanyTechnische Universität Dresden, B CUBE, Tatzberg 41, Dresden, GermanyDZD-Paul Langerhans Institute Dresden, Fetscherstraße 74, Dresden, GermanyMax Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstraße 108, Dresden, GermanyTechnische Universität Dresden, B CUBE, Tatzberg 41, Dresden, GermanyTechnische Universität Dresden, Medizinische Fakultät, Fetscherstraße 74, Dresden, GermanyTechnische Universität Dresden, B CUBE, Tatzberg 41, Dresden, Germany; Corresponding authorSummary: Cells, from microbes to mammals, adapt their membrane lipid composition in response to environmental changes to maintain optimal properties. Global patterns of lipidome remodeling are poorly understood, particularly in organisms with simple lipid compositions that can provide insight into fundamental principles of membrane adaptation. Using shotgun lipidomics, we examine the simple yet, as we show here, adaptive lipidome of the plant-associated Gram-negative bacterium Methylobacterium extorquens. We observe that minimally 11 lipids account for 90% of total variability, thus constraining the upper limit of variable lipids required for an adaptive living membrane. Through lipid features analysis, we reveal that acyl chain remodeling is not evenly distributed across lipid classes, resulting in headgroup-specific effects of acyl chain variability on membrane properties. Results herein implicate headgroup-specific acyl chain remodeling as a mechanism for fine-tuning the membrane’s physical state and provide a resource for using M. extorquens to explore the design principles of living membranes.http://www.sciencedirect.com/science/article/pii/S2211124720311542membrane adaptationhomeoviscous adaptationlipidomic remodelinglipidome resourcemembrane bioengineeringbacteria-host interactions |
| spellingShingle | Grzegorz Chwastek Michal A. Surma Sandra Rizk Daniel Grosser Oksana Lavrynenko Magdalena Rucińska Helena Jambor James Sáenz Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling Cell Reports membrane adaptation homeoviscous adaptation lipidomic remodeling lipidome resource membrane bioengineering bacteria-host interactions |
| title | Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling |
| title_full | Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling |
| title_fullStr | Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling |
| title_full_unstemmed | Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling |
| title_short | Principles of Membrane Adaptation Revealed through Environmentally Induced Bacterial Lipidome Remodeling |
| title_sort | principles of membrane adaptation revealed through environmentally induced bacterial lipidome remodeling |
| topic | membrane adaptation homeoviscous adaptation lipidomic remodeling lipidome resource membrane bioengineering bacteria-host interactions |
| url | http://www.sciencedirect.com/science/article/pii/S2211124720311542 |
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