Steroids in childhood epilepsy
Treatment of epileptic encephalopathies can be very challenging as most anticonvulsant drugs fail to achieve good seizure control. Steroids are disease modifying as well as anticonvulsant in these conditions. Though steroids are accepted as the first-line treatment for infantile spasms, there are ma...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2006-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.bioline.org.br/request?06051 |
| _version_ | 1819052645225070592 |
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| author | Ramachandrannair Rajesh |
| author_facet | Ramachandrannair Rajesh |
| author_sort | Ramachandrannair Rajesh |
| collection | DOAJ |
| description | Treatment of epileptic encephalopathies can be very challenging as most anticonvulsant drugs fail to achieve good seizure control. Steroids are disease modifying as well as anticonvulsant in these conditions. Though steroids are accepted as the first-line treatment for infantile spasms, there are many unanswered questions with regard to the preparation, dose and duration of treatment. In this review a re-exploration of the literature is attempted. Putative mechanism of action of steroids in infantile spasms is also discussed. As steroids are being increasingly used in other epileptic encephalopathies and Rasmussen′s encephalitis, a brief discussion on the role of steroids in these conditions is attempted. The review ends with the discussion on newer neuroactive steroids in the management of epilepsy. |
| first_indexed | 2024-12-21T12:23:07Z |
| format | Article |
| id | doaj.art-0f1edc1863dc4093849bfe07631c7843 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 |
| language | English |
| last_indexed | 2024-12-21T12:23:07Z |
| publishDate | 2006-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-0f1edc1863dc4093849bfe07631c78432022-12-21T19:04:15ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23272006-01-0194199206Steroids in childhood epilepsyRamachandrannair RajeshTreatment of epileptic encephalopathies can be very challenging as most anticonvulsant drugs fail to achieve good seizure control. Steroids are disease modifying as well as anticonvulsant in these conditions. Though steroids are accepted as the first-line treatment for infantile spasms, there are many unanswered questions with regard to the preparation, dose and duration of treatment. In this review a re-exploration of the literature is attempted. Putative mechanism of action of steroids in infantile spasms is also discussed. As steroids are being increasingly used in other epileptic encephalopathies and Rasmussen′s encephalitis, a brief discussion on the role of steroids in these conditions is attempted. The review ends with the discussion on newer neuroactive steroids in the management of epilepsy.http://www.bioline.org.br/request?06051ACTHchildhood epilepsyepileptic encephalopathyinfantile spasmsneurosteroidssteroids |
| spellingShingle | Ramachandrannair Rajesh Steroids in childhood epilepsy Annals of Indian Academy of Neurology ACTH childhood epilepsy epileptic encephalopathy infantile spasms neurosteroids steroids |
| title | Steroids in childhood epilepsy |
| title_full | Steroids in childhood epilepsy |
| title_fullStr | Steroids in childhood epilepsy |
| title_full_unstemmed | Steroids in childhood epilepsy |
| title_short | Steroids in childhood epilepsy |
| title_sort | steroids in childhood epilepsy |
| topic | ACTH childhood epilepsy epileptic encephalopathy infantile spasms neurosteroids steroids |
| url | http://www.bioline.org.br/request?06051 |
| work_keys_str_mv | AT ramachandrannairrajesh steroidsinchildhoodepilepsy |