The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases

The Regulatory Role of the Central and Peripheral Serotonin Network on Feeding Signals in Metabolic Diseases

Central and peripheral serotonin (5-hydroxytryptamine, 5-HT) regulate feeding signals for energy metabolism. Disruption of central 5-HT signaling via 5-HT2C receptors (5-HT2CRs) induces leptin-independent hyperphagia in mice, leading to late-onset obesity, insulin resistance, and impaired glucose to...

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Bibliographic Details
Main Author: Katsunori Nonogaki
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
serotonin
feeding signals
energy metabolism
5-HT2CRs
FGF21
obesity
Online Access:https://www.mdpi.com/1422-0067/23/3/1600

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