X-ray cross-complementing family: the bridge linking DNA damage repair and cancer
Abstract Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging factors that, if not repaired in time, can affect the transmission of genetic information and lead to cellular carcinogenesis. In response to thes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-023-04447-2 |
| _version_ | 1797451663421734912 |
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| author | Qiang Liu Qiu Peng Bin Zhang Yueqiu Tan |
| author_facet | Qiang Liu Qiu Peng Bin Zhang Yueqiu Tan |
| author_sort | Qiang Liu |
| collection | DOAJ |
| description | Abstract Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging factors that, if not repaired in time, can affect the transmission of genetic information and lead to cellular carcinogenesis. In response to these threats, cells have evolved a range of DNA damage response mechanisms, including DNA damage repair, to maintain genomic stability. The X-ray repair cross-complementary gene family (XRCC) comprises an important class of DNA damage repair genes that encode proteins that play important roles in DNA single-strand breakage and DNA base damage repair. The dysfunction of the XRCC gene family is associated with the development of various tumours. In the context of tumours, mutations in XRCC and its aberrant expression, result in abnormal DNA damage repair, thus contributing to the malignant progression of tumour cells. In this review, we summarise the significant roles played by XRCC in diverse tumour types. In addition, we discuss the correlation between the XRCC family members and tumour therapeutic sensitivity. |
| first_indexed | 2024-03-09T14:57:45Z |
| format | Article |
| id | doaj.art-0f225c785be0495084178f04b6a7c552 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-03-09T14:57:45Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-0f225c785be0495084178f04b6a7c5522023-11-26T14:05:02ZengBMCJournal of Translational Medicine1479-58762023-09-0121111410.1186/s12967-023-04447-2X-ray cross-complementing family: the bridge linking DNA damage repair and cancerQiang Liu0Qiu Peng1Bin Zhang2Yueqiu Tan3Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityHunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South UniversityAbstract Genomic instability is a common hallmark of human tumours. As a carrier of genetic information, DNA is constantly threatened by various damaging factors that, if not repaired in time, can affect the transmission of genetic information and lead to cellular carcinogenesis. In response to these threats, cells have evolved a range of DNA damage response mechanisms, including DNA damage repair, to maintain genomic stability. The X-ray repair cross-complementary gene family (XRCC) comprises an important class of DNA damage repair genes that encode proteins that play important roles in DNA single-strand breakage and DNA base damage repair. The dysfunction of the XRCC gene family is associated with the development of various tumours. In the context of tumours, mutations in XRCC and its aberrant expression, result in abnormal DNA damage repair, thus contributing to the malignant progression of tumour cells. In this review, we summarise the significant roles played by XRCC in diverse tumour types. In addition, we discuss the correlation between the XRCC family members and tumour therapeutic sensitivity.https://doi.org/10.1186/s12967-023-04447-2X-ray repair cross-complementary geneXRCCCancerDNA damage repairGenomic instability |
| spellingShingle | Qiang Liu Qiu Peng Bin Zhang Yueqiu Tan X-ray cross-complementing family: the bridge linking DNA damage repair and cancer Journal of Translational Medicine X-ray repair cross-complementary gene XRCC Cancer DNA damage repair Genomic instability |
| title | X-ray cross-complementing family: the bridge linking DNA damage repair and cancer |
| title_full | X-ray cross-complementing family: the bridge linking DNA damage repair and cancer |
| title_fullStr | X-ray cross-complementing family: the bridge linking DNA damage repair and cancer |
| title_full_unstemmed | X-ray cross-complementing family: the bridge linking DNA damage repair and cancer |
| title_short | X-ray cross-complementing family: the bridge linking DNA damage repair and cancer |
| title_sort | x ray cross complementing family the bridge linking dna damage repair and cancer |
| topic | X-ray repair cross-complementary gene XRCC Cancer DNA damage repair Genomic instability |
| url | https://doi.org/10.1186/s12967-023-04447-2 |
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