Palmitoylated Proteins in Dendritic Spine Remodeling
Activity-responsive changes in the actin cytoskeleton are required for the biogenesis, motility, and remodeling of dendritic spines. These changes are governed by proteins that regulate the polymerization, depolymerization, bundling, and branching of actin filaments. Thus, processes that have been e...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsyn.2020.00022/full |
| _version_ | 1811224420322115584 |
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| author | Joseph P. Albanesi Barbara Barylko George N. DeMartino David M. Jameson |
| author_facet | Joseph P. Albanesi Barbara Barylko George N. DeMartino David M. Jameson |
| author_sort | Joseph P. Albanesi |
| collection | DOAJ |
| description | Activity-responsive changes in the actin cytoskeleton are required for the biogenesis, motility, and remodeling of dendritic spines. These changes are governed by proteins that regulate the polymerization, depolymerization, bundling, and branching of actin filaments. Thus, processes that have been extensively characterized in the context of non-neuronal cell shape change and migration are also critical for learning and memory. In this review article, we highlight actin regulatory proteins that associate, at least transiently, with the dendritic plasma membrane. All of these proteins have been shown, either in directed studies or in high—throughput screens, to undergo palmitoylation, a potentially reversible, and stimulus-dependent cysteine modification. Palmitoylation increases the affinity of peripheral proteins for the membrane bilayer and contributes to their subcellular localization and recruitment to cholesterol-rich membrane microdomains. |
| first_indexed | 2024-04-12T08:49:04Z |
| format | Article |
| id | doaj.art-0f228e9c08824377aa27dd5395828309 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-04-12T08:49:04Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-0f228e9c08824377aa27dd53958283092022-12-22T03:39:38ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632020-06-011210.3389/fnsyn.2020.00022537415Palmitoylated Proteins in Dendritic Spine RemodelingJoseph P. Albanesi0Barbara Barylko1George N. DeMartino2David M. Jameson3Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, United StatesDepartment of Cell and Molecular Biology, University of Hawaii, Honolulu, HI, United StatesActivity-responsive changes in the actin cytoskeleton are required for the biogenesis, motility, and remodeling of dendritic spines. These changes are governed by proteins that regulate the polymerization, depolymerization, bundling, and branching of actin filaments. Thus, processes that have been extensively characterized in the context of non-neuronal cell shape change and migration are also critical for learning and memory. In this review article, we highlight actin regulatory proteins that associate, at least transiently, with the dendritic plasma membrane. All of these proteins have been shown, either in directed studies or in high—throughput screens, to undergo palmitoylation, a potentially reversible, and stimulus-dependent cysteine modification. Palmitoylation increases the affinity of peripheral proteins for the membrane bilayer and contributes to their subcellular localization and recruitment to cholesterol-rich membrane microdomains.https://www.frontiersin.org/article/10.3389/fnsyn.2020.00022/fullpalmitoylationdendritic spinescytoskeletal remodelingactin assemblysynaptic plasticity |
| spellingShingle | Joseph P. Albanesi Barbara Barylko George N. DeMartino David M. Jameson Palmitoylated Proteins in Dendritic Spine Remodeling Frontiers in Synaptic Neuroscience palmitoylation dendritic spines cytoskeletal remodeling actin assembly synaptic plasticity |
| title | Palmitoylated Proteins in Dendritic Spine Remodeling |
| title_full | Palmitoylated Proteins in Dendritic Spine Remodeling |
| title_fullStr | Palmitoylated Proteins in Dendritic Spine Remodeling |
| title_full_unstemmed | Palmitoylated Proteins in Dendritic Spine Remodeling |
| title_short | Palmitoylated Proteins in Dendritic Spine Remodeling |
| title_sort | palmitoylated proteins in dendritic spine remodeling |
| topic | palmitoylation dendritic spines cytoskeletal remodeling actin assembly synaptic plasticity |
| url | https://www.frontiersin.org/article/10.3389/fnsyn.2020.00022/full |
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