Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging
Abstract Right ventricular (RV) dilatation predicts clinical worsening in pulmonary arterial hypertension (PAH) and RV volumes can be measured with high precision using cardiovascular magnetic resonance imaging. In regular follow‐up of patients and in studies of improvement in RV function, knowledge...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-07-01
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| Series: | Pulmonary Circulation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pul2.12097 |
| _version_ | 1811185582953463808 |
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| author | Christoffer Göransson Niels Vejlstrup Jørn Carlsen |
| author_facet | Christoffer Göransson Niels Vejlstrup Jørn Carlsen |
| author_sort | Christoffer Göransson |
| collection | DOAJ |
| description | Abstract Right ventricular (RV) dilatation predicts clinical worsening in pulmonary arterial hypertension (PAH) and RV volumes can be measured with high precision using cardiovascular magnetic resonance imaging. In regular follow‐up of patients and in studies of improvement in RV function, knowledge of clinically significant changes of RV volumes and function are of relevance. Patients with PAH were followed with cardiovascular magnetic resonance imaging and clinical assessment at 6‐month intervals. Changes in RV volumes associated with changes in clinical status were assessed. Twenty‐five patients with PAH (Group 1) were included and examined every 6 months for 2.5 years, with a total of 107 MRI scans. For a step change in WHO functional class, the associated change in RV volume was 11% (confidence interval 7%−14%, p < 0.0001) and in stroke volume 9% (confidence interval 3%−15%, p = 0.003). This study found an 11% change in RV volume to be clinically significant. The combination of clinically significant changes and the known precision in the measurements enables individualized follow‐up of RV‐function in PAH. To our knowledge, this study is the first to use repeated assessments to suggest clinically significant changes of RV volume based on changes in clinical presentation. |
| first_indexed | 2024-04-11T13:32:50Z |
| format | Article |
| id | doaj.art-0f239ef1e96e40a49ead878fbb49338c |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-11T13:32:50Z |
| publishDate | 2022-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-0f239ef1e96e40a49ead878fbb49338c2022-12-22T04:21:44ZengWileyPulmonary Circulation2045-89402022-07-01123n/an/a10.1002/pul2.12097Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imagingChristoffer Göransson0Niels Vejlstrup1Jørn Carlsen2Department of Cardiology, Rigshospitalet Copenhagen University Hospital Copenhagen DenmarkDepartment of Cardiology, Rigshospitalet Copenhagen University Hospital Copenhagen DenmarkDepartment of Cardiology, Rigshospitalet Copenhagen University Hospital Copenhagen DenmarkAbstract Right ventricular (RV) dilatation predicts clinical worsening in pulmonary arterial hypertension (PAH) and RV volumes can be measured with high precision using cardiovascular magnetic resonance imaging. In regular follow‐up of patients and in studies of improvement in RV function, knowledge of clinically significant changes of RV volumes and function are of relevance. Patients with PAH were followed with cardiovascular magnetic resonance imaging and clinical assessment at 6‐month intervals. Changes in RV volumes associated with changes in clinical status were assessed. Twenty‐five patients with PAH (Group 1) were included and examined every 6 months for 2.5 years, with a total of 107 MRI scans. For a step change in WHO functional class, the associated change in RV volume was 11% (confidence interval 7%−14%, p < 0.0001) and in stroke volume 9% (confidence interval 3%−15%, p = 0.003). This study found an 11% change in RV volume to be clinically significant. The combination of clinically significant changes and the known precision in the measurements enables individualized follow‐up of RV‐function in PAH. To our knowledge, this study is the first to use repeated assessments to suggest clinically significant changes of RV volume based on changes in clinical presentation.https://doi.org/10.1002/pul2.12097magnetic resonance imagingminimal clinically important differenceright ventricle |
| spellingShingle | Christoffer Göransson Niels Vejlstrup Jørn Carlsen Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging Pulmonary Circulation magnetic resonance imaging minimal clinically important difference right ventricle |
| title | Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| title_full | Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| title_fullStr | Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| title_full_unstemmed | Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| title_short | Clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| title_sort | clinically important changes in right ventricular volume and function in pulmonary arterial hypertension assessed with cardiac magnetic resonance imaging |
| topic | magnetic resonance imaging minimal clinically important difference right ventricle |
| url | https://doi.org/10.1002/pul2.12097 |
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