(INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing
Rare-earth-doped inorganic nanocrystals are an important class of nanoparticles for bioimaging applications due to the facility of providing them with tailored emissions in the visible and near-infrared regions of the electromagnetic spectrum. Recently it has become of interest to engineer the dopan...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Optical Materials: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590147822000894 |
| _version_ | 1811168384014876672 |
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| author | Jingke Yao Gabriel López-Peña José Lifante M. Carmen Iglesias-de la Cruz Riccardo Marin Emma Martín Rodríguez Daniel Jaque Dirk H. Ortgies |
| author_facet | Jingke Yao Gabriel López-Peña José Lifante M. Carmen Iglesias-de la Cruz Riccardo Marin Emma Martín Rodríguez Daniel Jaque Dirk H. Ortgies |
| author_sort | Jingke Yao |
| collection | DOAJ |
| description | Rare-earth-doped inorganic nanocrystals are an important class of nanoparticles for bioimaging applications due to the facility of providing them with tailored emissions in the visible and near-infrared regions of the electromagnetic spectrum. Recently it has become of interest to engineer the dopant composition of these materials in order to enable multiplexed lifetime imaging for autofluorescence-free in vivo bioimaging. Herein we report a simple approach to obtain different fluorescence lifetimes for the Yb3+emission (2F5/2 → 2F7/2) in Nd3+, Yb3+, Tm3+ co-doped NaGdF4 nanoparticles by only changing their crystal size while keeping their hydrodynamic diameter constant. This allowed straightforward transformation of infrared images in the time domain into lifetime maps. The particles were then deployed as in vivo contrast agents for near-infrared imaging in a mouse demonstrating their multiplexing capability. |
| first_indexed | 2024-04-10T16:26:28Z |
| format | Article |
| id | doaj.art-0f23a0e12a0342d7b4da2a54fb7e53d0 |
| institution | Directory Open Access Journal |
| issn | 2590-1478 |
| language | English |
| last_indexed | 2024-04-10T16:26:28Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Optical Materials: X |
| spelling | doaj.art-0f23a0e12a0342d7b4da2a54fb7e53d02023-02-09T04:14:51ZengElsevierOptical Materials: X2590-14782023-02-0117100225(INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexingJingke Yao0Gabriel López-Peña1José Lifante2M. Carmen Iglesias-de la Cruz3Riccardo Marin4Emma Martín Rodríguez5Daniel Jaque6Dirk H. Ortgies7Nanomaterials for BioImaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Física Aplicada, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Fisiología, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28029, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Fisiología, Universidad Autónoma de Madrid, C/ Arzobispo Morcillo s/n, 28029, Madrid, Spain; Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Ctra de Colmenar km 9,300, 28034, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Física Aplicada, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, Spain; Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Ctra de Colmenar km 9,300, 28034, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, Spain; Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Ctra de Colmenar km 9,300, 28034, Madrid, SpainNanomaterials for BioImaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, Spain; Nanomaterials for BioImaging Group, Instituto Ramón y Cajal de Investigación Sanitaria IRYCIS, Ctra de Colmenar km 9,300, 28034, Madrid, Spain; Corresponding author. Nanomaterials for BioImaging Group, Departamento de Física de Materiales, Universidad Autónoma de Madrid, C/ Francisco Tomás y Valiente 7, 28049, Madrid, Spain.Rare-earth-doped inorganic nanocrystals are an important class of nanoparticles for bioimaging applications due to the facility of providing them with tailored emissions in the visible and near-infrared regions of the electromagnetic spectrum. Recently it has become of interest to engineer the dopant composition of these materials in order to enable multiplexed lifetime imaging for autofluorescence-free in vivo bioimaging. Herein we report a simple approach to obtain different fluorescence lifetimes for the Yb3+emission (2F5/2 → 2F7/2) in Nd3+, Yb3+, Tm3+ co-doped NaGdF4 nanoparticles by only changing their crystal size while keeping their hydrodynamic diameter constant. This allowed straightforward transformation of infrared images in the time domain into lifetime maps. The particles were then deployed as in vivo contrast agents for near-infrared imaging in a mouse demonstrating their multiplexing capability.http://www.sciencedirect.com/science/article/pii/S2590147822000894Rare-earth-doped nanoparticlesBioimagingInfrared imagingMultiplexingFluorescence lifetime |
| spellingShingle | Jingke Yao Gabriel López-Peña José Lifante M. Carmen Iglesias-de la Cruz Riccardo Marin Emma Martín Rodríguez Daniel Jaque Dirk H. Ortgies (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing Optical Materials: X Rare-earth-doped nanoparticles Bioimaging Infrared imaging Multiplexing Fluorescence lifetime |
| title | (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing |
| title_full | (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing |
| title_fullStr | (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing |
| title_full_unstemmed | (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing |
| title_short | (INVITED)Adjustable near-infrared fluorescence lifetime emission of biocompatible rare-earth-doped nanoparticles for in vivo multiplexing |
| title_sort | invited adjustable near infrared fluorescence lifetime emission of biocompatible rare earth doped nanoparticles for in vivo multiplexing |
| topic | Rare-earth-doped nanoparticles Bioimaging Infrared imaging Multiplexing Fluorescence lifetime |
| url | http://www.sciencedirect.com/science/article/pii/S2590147822000894 |
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