Hepatic Proteomic Changes and Sirt1/AMPK Signaling Activation by Oxymatrine Treatment in Rats With Non-alcoholic Steatosis

Hepatic Proteomic Changes and Sirt1/AMPK Signaling Activation by Oxymatrine Treatment in Rats With Non-alcoholic Steatosis

BackgroundCurrently, active ingredients of herbal extracts that can suppress lipid accumulation in the liver have been considered a potential treatment option for non-alcoholic fatty liver disease.MethodsSteatosis rat model was created by high fat and high sucrose diet feeding and treated with oxyma...

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Bibliographic Details
Main Authors: Hong Xu, Gao-Feng Chen, Yu-Shui Ma, Hong-Wei Zhang, Yang Zhou, Guang-Hui Liu, Dong-Ya Chen, Jian Ping, Yi-Hui Liu, Xin Mou, Da Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
NAFLD
proteomic
iTRAQ
oxymatrine
sirtuin 1
AMPK
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00216/full

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