A Systematic Review of Atypical Endometriosis-Associated Biomarkers
Ovarian endometriosis may increase the risk of malignancy. Several studies have suggested atypical endometriosis as the direct precursor of endometriosis-associated ovarian cancer. We performed an advanced, systematic search of the online medical databases PubMed and Medline. The search revealed <...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/8/4425 |
| _version_ | 1797434470890995712 |
|---|---|
| author | Ludovica Bartiromo Matteo Schimberni Roberta Villanacci Giorgia Mangili Stefano Ferrari Jessica Ottolina Noemi Salmeri Carolina Dolci Iacopo Tandoi Massimo Candiani |
| author_facet | Ludovica Bartiromo Matteo Schimberni Roberta Villanacci Giorgia Mangili Stefano Ferrari Jessica Ottolina Noemi Salmeri Carolina Dolci Iacopo Tandoi Massimo Candiani |
| author_sort | Ludovica Bartiromo |
| collection | DOAJ |
| description | Ovarian endometriosis may increase the risk of malignancy. Several studies have suggested atypical endometriosis as the direct precursor of endometriosis-associated ovarian cancer. We performed an advanced, systematic search of the online medical databases PubMed and Medline. The search revealed <i>n</i> = 40 studies eligible for inclusion in this systematic review. Of these, <i>n</i> = 39 were finally included. The results from included studies are characterized by high heterogeneity, but some consistency has been found for altered expression in phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway, ARID1a, estrogen and progesterone receptors, transcriptional, nuclear, and growth factors in atypical endometriosis. Although many targets have been proposed as biomarkers for the presence of atypical endometriosis, none of them has such strong evidence to justify their systematic use in clinical practice, and they all need expensive molecular analyses. Further well-designed studies are needed to validate the evidence on available biomarkers and to investigate novel serum markers for atypical endometriosis. |
| first_indexed | 2024-03-09T10:33:43Z |
| format | Article |
| id | doaj.art-0f2402247936459e819f91cd09bd4bb4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:33:43Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-0f2402247936459e819f91cd09bd4bb42023-12-01T21:04:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238442510.3390/ijms23084425A Systematic Review of Atypical Endometriosis-Associated BiomarkersLudovica Bartiromo0Matteo Schimberni1Roberta Villanacci2Giorgia Mangili3Stefano Ferrari4Jessica Ottolina5Noemi Salmeri6Carolina Dolci7Iacopo Tandoi8Massimo Candiani9Gynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyGynecology/Obstetrics Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, ItalyOvarian endometriosis may increase the risk of malignancy. Several studies have suggested atypical endometriosis as the direct precursor of endometriosis-associated ovarian cancer. We performed an advanced, systematic search of the online medical databases PubMed and Medline. The search revealed <i>n</i> = 40 studies eligible for inclusion in this systematic review. Of these, <i>n</i> = 39 were finally included. The results from included studies are characterized by high heterogeneity, but some consistency has been found for altered expression in phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway, ARID1a, estrogen and progesterone receptors, transcriptional, nuclear, and growth factors in atypical endometriosis. Although many targets have been proposed as biomarkers for the presence of atypical endometriosis, none of them has such strong evidence to justify their systematic use in clinical practice, and they all need expensive molecular analyses. Further well-designed studies are needed to validate the evidence on available biomarkers and to investigate novel serum markers for atypical endometriosis.https://www.mdpi.com/1422-0067/23/8/4425endometriosisatypicalatypical endometriosismarkerbiomarkeratypia |
| spellingShingle | Ludovica Bartiromo Matteo Schimberni Roberta Villanacci Giorgia Mangili Stefano Ferrari Jessica Ottolina Noemi Salmeri Carolina Dolci Iacopo Tandoi Massimo Candiani A Systematic Review of Atypical Endometriosis-Associated Biomarkers International Journal of Molecular Sciences endometriosis atypical atypical endometriosis marker biomarker atypia |
| title | A Systematic Review of Atypical Endometriosis-Associated Biomarkers |
| title_full | A Systematic Review of Atypical Endometriosis-Associated Biomarkers |
| title_fullStr | A Systematic Review of Atypical Endometriosis-Associated Biomarkers |
| title_full_unstemmed | A Systematic Review of Atypical Endometriosis-Associated Biomarkers |
| title_short | A Systematic Review of Atypical Endometriosis-Associated Biomarkers |
| title_sort | systematic review of atypical endometriosis associated biomarkers |
| topic | endometriosis atypical atypical endometriosis marker biomarker atypia |
| url | https://www.mdpi.com/1422-0067/23/8/4425 |
| work_keys_str_mv | AT ludovicabartiromo asystematicreviewofatypicalendometriosisassociatedbiomarkers AT matteoschimberni asystematicreviewofatypicalendometriosisassociatedbiomarkers AT robertavillanacci asystematicreviewofatypicalendometriosisassociatedbiomarkers AT giorgiamangili asystematicreviewofatypicalendometriosisassociatedbiomarkers AT stefanoferrari asystematicreviewofatypicalendometriosisassociatedbiomarkers AT jessicaottolina asystematicreviewofatypicalendometriosisassociatedbiomarkers AT noemisalmeri asystematicreviewofatypicalendometriosisassociatedbiomarkers AT carolinadolci asystematicreviewofatypicalendometriosisassociatedbiomarkers AT iacopotandoi asystematicreviewofatypicalendometriosisassociatedbiomarkers AT massimocandiani asystematicreviewofatypicalendometriosisassociatedbiomarkers AT ludovicabartiromo systematicreviewofatypicalendometriosisassociatedbiomarkers AT matteoschimberni systematicreviewofatypicalendometriosisassociatedbiomarkers AT robertavillanacci systematicreviewofatypicalendometriosisassociatedbiomarkers AT giorgiamangili systematicreviewofatypicalendometriosisassociatedbiomarkers AT stefanoferrari systematicreviewofatypicalendometriosisassociatedbiomarkers AT jessicaottolina systematicreviewofatypicalendometriosisassociatedbiomarkers AT noemisalmeri systematicreviewofatypicalendometriosisassociatedbiomarkers AT carolinadolci systematicreviewofatypicalendometriosisassociatedbiomarkers AT iacopotandoi systematicreviewofatypicalendometriosisassociatedbiomarkers AT massimocandiani systematicreviewofatypicalendometriosisassociatedbiomarkers |